2-(4-{2-[[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-N-(3,4-dihydroxy-butyl)-5-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide

Base Information

Chemical Name:2-(4-{2-[[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-N-(3,4-dihydroxy-butyl)-5-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide
CAS No.:179097-03-1
Molecular Formula:C₅₇H₇₄N₂O₆Si
Molecular Weight:911.31
Hs Code.:

2-(4-{2-[[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-N-(3,4-dihydroxy-butyl)-5-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide

Synonyms:2-(4-{2-[[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-N-(3,4-dihydroxy-butyl)-5-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide

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Chemical Property of 2-(4-{2-[[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-N-(3,4-dihydroxy-butyl)-5-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide

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Technology Process of 2-(4-{2-[[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-N-(3,4-dihydroxy-butyl)-5-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide

There total 14 articles about 2-(4-{2-[[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-N-(3,4-dihydroxy-butyl)-5-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 179096-57-2
1-{2-[N-(α,α-dimethylbenzyl)-N-but-3-enylcarbamoyl]-4-methylphenyl}-4-[2-(N-(1-ethylcyclopentyl)-N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}carbamoyl)phenyl]-2-butanol

: 179097-03-1
2-(4-{2-[[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-N-(3,4-dihydroxy-butyl)-5-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; tert-butyl alcohol; In water; acetone;
DOI:10.1021/jm960092w

Reference yield:

: 67404-87-9
1-ethylcyclopentan-1-amine

: 179097-03-1
2-(4-{2-[[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-N-(3,4-dihydroxy-butyl)-5-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) LiClO₄ / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₃CN, RT, 3 h

2: imidazole / CH₂Cl₂ / 18 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 21 h / Ambient temperature

4: 1.) diisopropylamine, sec-butyllithium / 1.) THF, -70 deg C, 1.5 h, 2.) THF, RT, 16 h

5: Jone's reagent / acetone

6: DEPC, diisopropylethylamine / CH₂Cl₂ / 2 h / Ambient temperature

7: 1.) diisopropylamine, sec-butyllithium / 1.) THF, cyclohexane, -78 deg C, 35 min, 2.) THF, cyclohexane, from -78 deg C to RT, 1 h

8: 99 percent / NaBH₄ / ethanol / Ambient temperature

9: 89 percent / N-methylmorpholine N-oxide, t-BuOH, OsO₄ / acetone; H₂O

With 1H-imidazole; sodium tetrahydroborate; osmium(VIII) oxide; Jones reagent; sec.-butyllithium; lithium perchlorate; 4-methylmorpholine N-oxide; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; diethyl dicarbonate; tert-butyl alcohol; In ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm960092w

Reference yield:

: 22328-43-4
2,5-dimethylbenzoyl chloride

: 179097-03-1
2-(4-{2-[[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-N-(3,4-dihydroxy-butyl)-5-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

2: 1.) diisopropylamine, sec-butyllithium / 1.) THF, cyclohexane, -78 deg C, 35 min, 2.) THF, cyclohexane, from -78 deg C to RT, 1 h

3: 99 percent / NaBH₄ / ethanol / Ambient temperature

4: 89 percent / N-methylmorpholine N-oxide, t-BuOH, OsO₄ / acetone; H₂O

With sodium tetrahydroborate; osmium(VIII) oxide; sec.-butyllithium; 4-methylmorpholine N-oxide; triethylamine; diisopropylamine; tert-butyl alcohol; In ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm960092w