(S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-pentanedioic acid

Base Information

Chemical Name:(S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-pentanedioic acid
CAS No.:113322-24-0
Molecular Formula:C₂₁H₂₅N₃O₈S
Molecular Weight:479.511
Hs Code.:

Synonyms:(S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-pentanedioic acid

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Chemical Property of (S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-pentanedioic acid

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Technology Process of (S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-pentanedioic acid

There total 3 articles about (S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 113322-10-4
(S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-pentanedioic acid bis-(2,2,2-trichloro-ethyl) ester

: 113322-24-0
(S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-pentanedioic acid

Guidance literature:: With acetic acid; zinc; In N,N-dimethyl-formamide; at 0 ℃; for 3h;
DOI:10.1021/jm00400a015

Reference yield:

: 113322-03-5
(S)-2-Amino-pentanedioic acid bis-(2,2,2-trichloro-ethyl) ester; hydrobromide

: 113322-24-0
(S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 26 percent / Et₃N, N,N-diisopropylcarbodiimide / CH₂Cl₂

2: 46 percent / HOAc, Zn / dimethylformamide / 3 h / 0 °C

With acetic acid; triethylamine; diisopropyl-carbodiimide; zinc; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00400a015

Reference yield:

: 87-08-1
penicilin V

: 113322-24-0
(S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 26 percent / Et₃N, N,N-diisopropylcarbodiimide / CH₂Cl₂

2: 46 percent / HOAc, Zn / dimethylformamide / 3 h / 0 °C

With acetic acid; triethylamine; diisopropyl-carbodiimide; zinc; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00400a015