1-(1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2-phenyl-5-(trifluoromethyl)-1H-indol-3-yl)ethanone

Base Information

Chemical Name:1-(1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2-phenyl-5-(trifluoromethyl)-1H-indol-3-yl)ethanone
CAS No.:1613132-99-2
Molecular Formula:C₂₀H₁₆F₃N₅OS
Molecular Weight:431.441
Hs Code.:

Synonyms:1-(1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2-phenyl-5-(trifluoromethyl)-1H-indol-3-yl)ethanone

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Chemical Property of 1-(1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2-phenyl-5-(trifluoromethyl)-1H-indol-3-yl)ethanone

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Technology Process of 1-(1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2-phenyl-5-(trifluoromethyl)-1H-indol-3-yl)ethanone

There total 6 articles about 1-(1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2-phenyl-5-(trifluoromethyl)-1H-indol-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1613132-87-8
C₁₈H₁₄F₃N₅S

: 108-24-7
acetic anhydride

: 1613132-99-2
1-(1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2-phenyl-5-(trifluoromethyl)-1H-indol-3-yl)ethanone

Guidance literature:: C₁₈H₁₄F₃N₅S; With tin(IV) chloride; In dichloromethane; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

acetic anhydride; In nitromethane; dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.04.043

Reference yield:

: 491601-38-8
2-phenyl-5-(trifluoromethyl)-1H-indole

: 1613132-99-2
1-(1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2-phenyl-5-(trifluoromethyl)-1H-indol-3-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / toluene / Reflux

2.1: sodium hydroxide / ethanol / 8 h / Reflux

3.1: potassium permanganate; ammonia / 0.25 h / 0 °C

4.1: tin(IV) chloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

4.2: 2 h / 20 °C / Inert atmosphere

With potassium permanganate; ammonia; tin(IV) chloride; potassium carbonate; sodium hydroxide; In ethanol; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2014.04.043

Reference yield:

: 1613132-75-4
C₁₇H₁₁ClF₃NO

: 1613132-99-2
1-(1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2-phenyl-5-(trifluoromethyl)-1H-indol-3-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol / 8 h / Reflux

2.1: potassium permanganate; ammonia / 0.25 h / 0 °C

3.1: tin(IV) chloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With potassium permanganate; ammonia; tin(IV) chloride; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.04.043