491601-38-8

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 6783-05-7 trans-2-phenylvinylboronic acid 
• 132839-58-8 2-bromo-1-nitro- 4-(trifluoromethyl)benzene 
• 100-42-5 styrene 
• 536-74-3 phenylacetylene 
• 163444-17-5 2-iodo-4-(trifluoromethyl)aniline 
• 440363-04-2 2-(2-trimethylsilylethynyl)-4-trifluoromethylaniline 
• 878133-02-9 2-ethynyl-4-(trifluoromethyl)aniline 
• 70-11-1 α-bromoacetophenone 
• 1033002-26-4 2-(2-phenylethynyl)-4-trifluoromethylphenylamine 
• 1449516-94-2 C₁₆H₁₀BrF₃N₂ 
• 1181455-10-6 C₁₅H₁₂F₃N₃ 
• 1181455-43-5 C₁₅H₁₀F₃N₃ 
• 1054566-84-5 C₁₅H₁₀F₃N₃ 

Downstream Products

• 1476035-15-0 1-phenyl-2-(2-phenyl-5-(trifluoromethyl)-1H-indol-3-yl)ethane-1,2-dione 
• 1417819-59-0 2-phenyl-6-(trifluoromethyl)-4H-benzo[d][1,3]oxazin-4-one 
• 1613132-75-4 C₁₇H₁₁ClF₃NO 
• 1613133-17-7 1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2-phenyl-5-(trifluoromethyl)-1H-indole-3-carboxamide 
• 1613133-11-1 1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2-phenyl-5-(trifluoromethyl)-1H-indole-3-carboxylic acid 
• 1613132-99-2 1-(1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2-phenyl-5-(trifluoromethyl)-1H-indol-3-yl)ethanone 
• 1613132-93-6 6-(3-allyl-2-phenyl-5-(trifluoromethyl)-1H-indol-1-yl)-5-amino-4,5-dihydro-1,2,4-triazine-3(2H)-thione 
• 1613132-87-8 C₁₈H₁₄F₃N₅S 
• 1613132-81-2 C₁₈H₁₃F₃N₄S 

Relevant academic research and scientific papers

Copper-Catalyzed Enantioselective C-H Arylation between 2-Arylindoles and Hypervalent Iodine Reagents

The copper-catalyzed enantioselective C-H arylation between 2-arylindoles and hypervalent iodine reagents has been successfully developed, which provides a convenient and economical route to the highly atroposelective synthesis of axially chiral indole de

Pd-Catalyzed Reductive Cyclization of Nitroarenes with CO2 as the CO Source

A reductive amination process that constructs indoles, carbazoles or benzimidazoles from nitroarenes – irrespective of their electronic or steric nature – was developed that uses CO2 as the source of CO. The process is robust, tolerating common gaseous components of flue gas (H2S, SO2, NO and H2O) without adversely affecting the reductive cyclization.

Chiral Br?nsted Acid from Chiral Phosphoric Acid Boron Complex and Water: Asymmetric Reduction of Indoles

A new chiral Br?nsted acid, generated in situ from a chiral phosphoric acid boron (CPAB) complex and water, was successfully applied to asymmetric indole reduction. This “designer acid catalyst”, which is more acidic than TsOH as suggested by DFT calculations, allows the unprecedented direct asymmetric reduction of C2-aryl-substituted N-unprotected indoles and features good to excellent enantioselectivities with broad functional group tolerance. DFT calculations and mechanistic experiments indicates that this reaction undergoes C3-protonation and hydride-transfer processes. Besides, bulky C2-alkyl-substituted N-unprotected indoles are also suitable for this system.

Iron-Catalyzed Reductive Cyclization of o-Nitrostyrenes Using Phenylsilane as the Terminal Reductant

Using microscale high-throughput experimentation, an efficient, earth-abundant iron phenanthroline complex was discovered to catalyze the reductive cyclization of ortho-nitrostyrenes into indoles via nitrosoarene reactive intermediates. This method requires only 1 mol % of Fe(OAc)2 and 1 mol % of 4,7-(MeO)2phen and uses phenylsilane as a convenient terminal reductant. The scope and limitations of the method were illustrated with 21 examples, and an investigation into the kinetics of the reaction revealed first-order behavior in catalyst and silane and zero-order behavior with respect to nitrostyrene.

Palladium-Catalyzed Formation of N-Heteroarenes from Nitroarenes using Molybdenum Hexacarbonyl as the Source of Carbon Monoxide

The development of a method that employs a two-chamber reaction vessel and uses molybdenum hexacarbonyl [Mo(CO)6] as the carbon monoxide (CO) source for the palladium-catalyzed transformation of nitroarenes into indoles or imidazoles is reported.

A Scalable Method for Regioselective 3-Acylation of 2-Substituted Indoles under Basic Conditions

Privileged structures such as 2-arylindoles are recurrent molecular scaffolds in bioactive molecules. We here present an operationally simple, high yielding and scalable method for regioselective 3-acylation of 2-substituted indoles under basic conditions

Anticonvulsant evaluation of clubbed indole-1,2,4-triazine derivatives: A synthetic approach

A series of thirty indole C-3 substituted 5-amino-6-(5-substituted-2- phenyl-1H-indol-1-yl)-4,5-dihydro-1,2,4-triazine-3(2H)-thione 5a-f, 6a-f, 7a-f, 8a-f and 9a-f were synthesized to explore prospective anticonvulsant agents. The derivative 1-(1-(5-amino

Palladium-catalyzed synthesis of 3-acylated indoles involving oxidative cross-coupling of indoles with α-amino carbonyl compounds

A new and selective C-N bond oxidative cleavage method to 3-acylated indoles by Pd-catalyzed oxidative cross coupling of indoles with α-amino carbonyl compounds has been developed; moreover, one-pot synthesis of 3-acylated indoles from 2-ethynylanilines and α-amino carbonyl compounds has also been established. Importantly, the products 3-acylated indoles can be used to construct polyheterocyclic compound, which can be employed as efficient probes for Hg2+ and Fe3+.

Copper-catalyzed ortho-halogenation of protected anilines

A practical Cu-catalyzed direct ortho-halogenation of anilines under aerobic conditions has been developed. The reaction shows typically excellent mono-substitution selectivity, high ortho-regiocontrol and large functional group tolerance.

PROCESSES FOR PREPARING INDOLES

Methods for the synthesis of an indole in provided. Methods comprise oxidizing a N-aryl imine in the presence of a palladium-based catalyst, an oxidant, and a solvent.