(6S)-1,4-di-O-benzyl-6-benzylamino-6-deoxy-2,3-O-isopropylidene-6-C-diethylphosphono-α-L-sorbofuranose

Base Information

Chemical Name:(6S)-1,4-di-O-benzyl-6-benzylamino-6-deoxy-2,3-O-isopropylidene-6-C-diethylphosphono-α-L-sorbofuranose
CAS No.:473931-86-1
Molecular Formula:C₃₄H₄₄NO₈P
Molecular Weight:625.699
Hs Code.:

Synonyms:(6S)-1,4-di-O-benzyl-6-benzylamino-6-deoxy-2,3-O-isopropylidene-6-C-diethylphosphono-α-L-sorbofuranose

Suppliers and Price of (6S)-1,4-di-O-benzyl-6-benzylamino-6-deoxy-2,3-O-isopropylidene-6-C-diethylphosphono-α-L-sorbofuranose

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (6S)-1,4-di-O-benzyl-6-benzylamino-6-deoxy-2,3-O-isopropylidene-6-C-diethylphosphono-α-L-sorbofuranose

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (6S)-1,4-di-O-benzyl-6-benzylamino-6-deoxy-2,3-O-isopropylidene-6-C-diethylphosphono-α-L-sorbofuranose

There total 10 articles about (6S)-1,4-di-O-benzyl-6-benzylamino-6-deoxy-2,3-O-isopropylidene-6-C-diethylphosphono-α-L-sorbofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 302788-34-7
3,6-di-O-benzyl-4,5-O-isopropylidene-D-xylo-aldehydohexos-5-ulo-2,5-furanose N-benzylimine

: 13716-45-5
diethyl trimethylsilyl phosphite

: 473931-86-1
(6S)-1,4-di-O-benzyl-6-benzylamino-6-deoxy-2,3-O-isopropylidene-6-C-diethylphosphono-α-L-sorbofuranose

Guidance literature:: In dichloromethane; at 40 ℃; for 0.75h;
DOI:10.1021/jo0203903

Reference yield: 76.0%

: 762-04-9
phosphonic acid diethyl ester

: 302788-34-7
3,6-di-O-benzyl-4,5-O-isopropylidene-D-xylo-aldehydohexos-5-ulo-2,5-furanose N-benzylimine

: (6R)-1,4-di-O-benzyl-6-benzylamino-6-deoxy-2,3-O-isopropylidene-6-C-diethylphosphono-α-L-sorbofuranose

: 473931-86-1
(6S)-1,4-di-O-benzyl-6-benzylamino-6-deoxy-2,3-O-isopropylidene-6-C-diethylphosphono-α-L-sorbofuranose

Guidance literature:: With zirconium(IV) chloride; In acetonitrile; at 20 ℃; for 1.5h; Title compound not separated from byproducts;
DOI:10.1021/jo0203903

Reference yield:

: 100-39-0
benzyl bromide

: 473931-86-1
(6S)-1,4-di-O-benzyl-6-benzylamino-6-deoxy-2,3-O-isopropylidene-6-C-diethylphosphono-α-L-sorbofuranose

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

1.2: 98 percent / tetrabutylammonium bromide / tetrahydrofuran / 3 h / 20 °C

2.1: 99 percent / H₂SO₄ / acetone; H₂O / 3 h / 20 °C

3.1: 95 percent / pyridine / 24 h / 50 °C

4.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

4.2: 99 percent / tetrabutylammonium bromide / tetrahydrofuran / 4 h / 20 °C

5.1: 96 percent / HBr / acetic acid / 10 - 15 °C

6.1: 91 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

7.1: 100 percent / molecular sieves 4 Angstroem / CH₂Cl₂ / 3 h / 4 °C

8.1: ZrCl₄ / acetonitrile / 1.5 h / 20 °C

With pyridine; 4 A molecular sieve; sulfuric acid; hydrogen bromide; zirconium(IV) chloride; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water; acetic acid; acetone; acetonitrile;
DOI:10.1021/jo0203903