(3S,3aS,7aR)-1,3,3a,6,7,7a-hexahydro-3-(4-methoxyphenyl)-1,1,5-trimethylisobenzofuran

Base Information

• Chemical Name: (3S,3aS,7aR)-1,3,3a,6,7,7a-hexahydro-3-(4-methoxyphenyl)-1,1,5-trimethylisobenzofuran
• CAS No.: 1260153-08-9
• Molecular Formula: C₁₈H₂₄O₂
• Molecular Weight: 272.387
• Mol file: 1260153-08-9.mol

Synonyms:(3S,3aS,7aR)-1,3,3a,6,7,7a-hexahydro-3-(4-methoxyphenyl)-1,1,5-trimethylisobenzofuran

Chemical Property of (3S,3aS,7aR)-1,3,3a,6,7,7a-hexahydro-3-(4-methoxyphenyl)-1,1,5-trimethylisobenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,3aS,7aR)-1,3,3a,6,7,7a-hexahydro-3-(4-methoxyphenyl)-1,1,5-trimethylisobenzofuran

There total 4 articles about (3S,3aS,7aR)-1,3,3a,6,7,7a-hexahydro-3-(4-methoxyphenyl)-1,1,5-trimethylisobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

2-carene (4497-92-1) + 4-methoxy-benzaldehyde (123-11-5) → (3S,3aS,7aR)-1,3,3a,6,7,7a-hexahydro-3-(4-methoxyphenyl)-1,1,5-trimethylisobenzofuran (1260153-08-9) + (3R,3aS,7aR)-1,3,3a,6,7,7a-hexahydro-3-(4-methoxyphenyl)-1,1,5-trimethylisobenzofuran (1260153-16-9) + 4-(4-methoxyphenyl)-2,2,6-trimethyl-3-oxabicyclo[3.3.1]non-6-ene

Guidance literature:

With montmorillonite K₁₀ clay; In dichloromethane; at 20 ℃; for 1.5h; optical yield given as %ee;

DOI:10.1002/hlca.201000145

Reference yield:

2-carene (4497-92-1) + 4-methoxy-benzaldehyde (123-11-5) → 4-methylisopropylbenzene (99-87-6) + (3S,3aS,7aR)-1,3,3a,6,7,7a-hexahydro-3-(4-methoxyphenyl)-1,1,5-trimethylisobenzofuran (1260153-08-9) + 3-p-menthene (500-00-5) + C18H24O2 + limonene. (138-86-3,555-08-8,8022-90-0,9003-73-0,95327-98-3)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In dichloromethane; at 40 ℃; for 3h;

DOI:10.1016/j.mcat.2020.110974

Reference yield:

2-carene (4497-92-1) + 4-methoxy-benzaldehyde (123-11-5) → (3S,3aS,7aR)-1,3,3a,6,7,7a-hexahydro-3-(4-methoxyphenyl)-1,1,5-trimethylisobenzofuran (1260153-08-9) + (3R,3aS,7aR)-1,3,3a,6,7,7a-hexahydro-3-(4-methoxyphenyl)-1,1,5-trimethylisobenzofuran (1260153-16-9)

Guidance literature:

With 5% HCl-treated halloysite nanotubes at 50 °C pretreatment drying; In cyclohexane; at 50 ℃; for 0.5h; Reagent/catalyst; Kinetics;

DOI:10.1016/j.mcat.2020.110974

upstream raw materials:

(+)-Δ³-carene

4-methoxy-benzaldehyde

2-carene