3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-4-hydroxy-3-(hydroxymethyl)butoxy)-2,6-difluorobenzamide

Base Information

Chemical Name:3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-4-hydroxy-3-(hydroxymethyl)butoxy)-2,6-difluorobenzamide
CAS No.:1403882-03-0
Molecular Formula:C₂₂H₁₈BrF₅N₂O₅
Molecular Weight:565.291
Hs Code.:

Synonyms:3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-4-hydroxy-3-(hydroxymethyl)butoxy)-2,6-difluorobenzamide

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Chemical Property of 3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-4-hydroxy-3-(hydroxymethyl)butoxy)-2,6-difluorobenzamide

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Technology Process of 3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-4-hydroxy-3-(hydroxymethyl)butoxy)-2,6-difluorobenzamide

There total 10 articles about 3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-4-hydroxy-3-(hydroxymethyl)butoxy)-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1403881-96-8
2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl)propane-1,3-diyl diacetate

: 1403882-03-0
3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-4-hydroxy-3-(hydroxymethyl)butoxy)-2,6-difluorobenzamide

Guidance literature:: 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl)propane-1,3-diyl diacetate; With potassium carbonate; In methanol; at 20 ℃; for 1h;

With water; In methanol;

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1403882-03-0
3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-4-hydroxy-3-(hydroxymethyl)butoxy)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: 2 h / 130 °C

2.1: sodium tetrahydroborate / methanol / 2 h / Cooling with ice; Reflux

3.1: triethylamine / dichloromethane / 20 °C / Cooling with ice

4.1: N-Bromosuccinimide; acetic acid / 20 °C

5.1: potassium carbonate / methanol / 1 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Cooling with ice

7.2: 4 h / 65 °C

8.1: sodium tetrahydroborate / methanol / 3 h / 65 °C

8.2: Cooling with ice

9.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

10.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

11.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

12.1: potassium carbonate / methanol / 1 h / 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1403884-42-3
2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl methanesulfonate

: 1403882-03-0
3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-4-hydroxy-3-(hydroxymethyl)butoxy)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Cooling with ice

1.2: 4 h / 65 °C

2.1: sodium tetrahydroborate / methanol / 3 h / 65 °C

2.2: Cooling with ice

3.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

4.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

6.1: potassium carbonate / methanol / 1 h / 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; mineral oil;