Technology Process of (+/-)-8-hydroxyleucoperezone
There total 9 articles about (+/-)-8-hydroxyleucoperezone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 82 percent / 90percent HNO3 / 0.17 h / -10 °C
2: 95 percent / H2 / 10percent palladized charcoal / methanol / 586 Torr / Ambient temperature
3: 70 percent / NaNO2 / aq. H2SO4 / 0.25 h / Ambient temperature; 50 deg C, 30 min
4: 82 percent / anhydrous potassium carbonate / acetone / 5 h / Heating
5: 1.) 1.6 M n-butyllithium / 1.) ethyl ether, hexane, 0 deg C, 30 min then room temperature; 2.) 0 deg C, 30 min
With
n-butyllithium; hydrogen; nitric acid; potassium carbonate; sodium nitrite;
palladium on activated charcoal;
In
methanol; sulfuric acid; acetone;
DOI:10.1016/S0040-4020(01)96630-X
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 95 percent / H2 / 10percent palladized charcoal / methanol / 586 Torr / Ambient temperature
2: 70 percent / NaNO2 / aq. H2SO4 / 0.25 h / Ambient temperature; 50 deg C, 30 min
3: 82 percent / anhydrous potassium carbonate / acetone / 5 h / Heating
4: 1.) 1.6 M n-butyllithium / 1.) ethyl ether, hexane, 0 deg C, 30 min then room temperature; 2.) 0 deg C, 30 min
With
n-butyllithium; hydrogen; potassium carbonate; sodium nitrite;
palladium on activated charcoal;
In
methanol; sulfuric acid; acetone;
DOI:10.1016/S0040-4020(01)96630-X
- Guidance literature:
-
Multi-step reaction with 6 steps
1: methylation
2: m-chloroperoxybenzoic acid / CHCl3 / 0.75 h / Heating
3: 8.949 g / aq. hydrochloric acid / methanol / 0.5 h / Ambient temperature
4: 93 percent / anhydrous potassium carbonate / acetone / 12 h / Ambient temperature
5: 1.) 1.5 M methyl lithium / 1.) ethyl ether, 0 deg C, 15 min; 2.) 0 deg C, 30 min
6: 1.) 1.6 M n-butyllithium / 1.) ethyl ether, hexane, 0 deg C, 30 min then room temperature; 2.) 0 deg C, 30 min
With
hydrogenchloride; n-butyllithium; methyllithium; potassium carbonate; 3-chloro-benzenecarboperoxoic acid;
In
methanol; chloroform; acetone;
DOI:10.1016/S0040-4020(01)96630-X
