4-Methoxy-thiobenzoic acid S-(5,5-dimethyl-2-thioxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl) ester

Base Information

• Chemical Name: 4-Methoxy-thiobenzoic acid S-(5,5-dimethyl-2-thioxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl) ester
• CAS No.: 317818-10-3
• Molecular Formula: C₁₃H₁₇O₄PS₂
• Molecular Weight: 332.381
• Mol file: 317818-10-3.mol

Synonyms:4-Methoxy-thiobenzoic acid S-(5,5-dimethyl-2-thioxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl) ester

Chemical Property of 4-Methoxy-thiobenzoic acid S-(5,5-dimethyl-2-thioxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methoxy-thiobenzoic acid S-(5,5-dimethyl-2-thioxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl) ester

There total 3 articles about 4-Methoxy-thiobenzoic acid S-(5,5-dimethyl-2-thioxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5,5-dimethyl-2-thiolo-2-thiono-1,3,2-dioxaphosphorinane (697-45-0) + 4-methoxy-benzoyl chloride (100-07-2) → 4-Methoxy-thiobenzoic acid S-(5,5-dimethyl-2-thioxo-2λ5-[1,3,2]dioxaphosphinan-2-yl) ester (317818-10-3)

Guidance literature:

With triethylamine; In benzene; for 0.25h; ice-cooling;

DOI:10.1039/b201233b

Reference yield:

5,5-dimethyl-2-thiolo-2-thiono-1,3,2-dioxaphosphorinane (697-45-0) + 4-methoxy-benzoyl chloride (100-07-2) → 4-Methoxy-thiobenzoic acid O-(5,5-dimethyl-2-thioxo-2λ5-[1,3,2]dioxaphosphinan-2-yl) ester + 4-Methoxy-thiobenzoic acid S-(5,5-dimethyl-2-thioxo-2λ5-[1,3,2]dioxaphosphinan-2-yl) ester (317818-10-3)

Guidance literature:

With pyridine; In benzene; for 0.25h; Title compound not separated from byproducts.;

DOI:10.1039/b005911k

Reference yield:

2,2-Dimethyl-1,3-propanediol (126-30-7) → 4-Methoxy-thiobenzoic acid S-(5,5-dimethyl-2-thioxo-2λ5-[1,3,2]dioxaphosphinan-2-yl) ester (317818-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 79.7 percent / P₂S₅ / benzene / 50 °C

2: 85 percent / Et₃N / benzene / 0.25 h / ice-cooling

With tetraphosphorus decasulfide; triethylamine; In benzene;

DOI:10.1039/b201233b

upstream raw materials:

5,5-dimethyl-2-thiolo-2-thiono-1,3,2-dioxaphosphorinane

4-methoxy-benzoyl chloride

2,2-Dimethyl-1,3-propanediol

Downstream raw materials:

4-methoxythiobenzoyl (5,5-dimethyl-2-oxo-1,3,2-dioxaphosphinan-2-yl) sulfide

4-methoxy-N,N-diethylbenzamide

N,N-diethyl-4-methoxythiobenzamide