6-chloro-3-(4-(methylsulfonyl)phenyl)imidazo[1,2-b]-pyridazine

Base Information

• Chemical Name: 6-chloro-3-(4-(methylsulfonyl)phenyl)imidazo[1,2-b]-pyridazine
• CAS No.: 1580454-37-0
• Molecular Formula: C₁₃H₁₀ClN₃O₂S
• Molecular Weight: 307.76
• Mol file: 1580454-37-0.mol

Synonyms:6-chloro-3-(4-(methylsulfonyl)phenyl)imidazo[1,2-b]-pyridazine

Chemical Property of 6-chloro-3-(4-(methylsulfonyl)phenyl)imidazo[1,2-b]-pyridazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-3-(4-(methylsulfonyl)phenyl)imidazo[1,2-b]-pyridazine

There total 2 articles about 6-chloro-3-(4-(methylsulfonyl)phenyl)imidazo[1,2-b]-pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

6-chloro-3-iodo-imidazo[1,2-b]pyridazine (923595-49-7) + 4-methanesulphonylphenylboronic acid (149104-88-1) → 6-chloro-3-(4-(methylsulfonyl)phenyl)imidazo[1,2-b]-pyridazine (1580454-37-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jm500098s

Reference yield:

6-chloroimidazo[1,2-b]pyridazine (6775-78-6) → 6-chloro-3-(4-(methylsulfonyl)phenyl)imidazo[1,2-b]-pyridazine (1580454-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-iodo-succinimide / N,N-dimethyl-formamide / 96 h / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; potassium carbonate; In N,N-dimethyl-formamide; 2: |Suzuki Coupling;

DOI:10.1021/jm500098s

Reference yield: 78.0%

3-(N,N-dimethylamino)phenylboronic acid (178752-79-9) + 6-chloro-3-(4-(methylsulfonyl)phenyl)imidazo[1,2-b]-pyridazine (1580454-37-0) → N,N-dimethyl-3-(3-(4-(methylsulfonyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)aniline (1580453-86-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jm500098s

upstream raw materials:

6-chloroimidazo[1,2-b]pyridazine

6-chloro-3-iodo-imidazo[1,2-b]pyridazine

4-methanesulphonylphenylboronic acid

Downstream raw materials:

3-(3-(4-(methylsulfonyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)benzenesulfonamide

C₂₅H₂₅N₅O₃S

C₂₄H₂₃FN₄O₃S

3-(4-(methylsulfonyl)phenyl)-6-(4-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine