6-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-hexanoic acid ethyl ester

Base Information

Chemical Name:6-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-hexanoic acid ethyl ester
CAS No.:860771-28-4
Molecular Formula:C₂₄H₃₁N₅O₄
Molecular Weight:453.541
Hs Code.:

6-[3-(2,4-diamino-5-methyl-pyrido[2,3-<i>d</i>]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-hexanoic acid ethyl ester

Synonyms:6-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-hexanoic acid ethyl ester

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Chemical Property of 6-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-hexanoic acid ethyl ester

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Technology Process of 6-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-hexanoic acid ethyl ester

There total 10 articles about 6-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-hexanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 118252-38-3
2,4-diamino-5-methyl-6-(2'-methoxy-5'-hydroxybenzyl)pyrido[2,3-d]pyrimidine

: 25542-62-5
6-bromo-hexanoic acid ethyl ester

: 860771-28-4
6-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-hexanoic acid ethyl ester

Guidance literature:: With sodium ethanolate; In dimethyl sulfoxide; at 20 ℃;
DOI:10.1021/jm0581718

Reference yield:

: 860771-20-6
2-[1-(5-Benzyloxy-2-methoxy-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid ethyl ester

: 860771-28-4
6-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-hexanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 18 g / H₂ / Pd/C / ethanol / 3 h / 1034.3 Torr

2.1: 1-methyl-pyrrolidin-2-one / 2 h / 190 °C

3.1: oxalyl chloride; DMF / CH₂Cl₂ / 3 h / Heating

3.2: n-BuNH₂ / CH₂Cl₂ / 1.5 h / Heating

4.1: sodium formate; Pd/C / 2-methoxy-ethanol / 4 h

5.1: 15 percent / NaOEt / dimethylsulfoxide / 20 °C

With palladium on activated charcoal; oxalyl dichloride; hydrogen; sodium ethanolate; sodium formate; N,N-dimethyl-formamide; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; 2-methoxy-ethanol; dimethyl sulfoxide;
DOI:10.1021/jm0581718

Reference yield:

: 52329-06-3
5-(benzyloxy)-2-methoxybenzaldehyde

: 860771-28-4
6-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenoxy]-hexanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: piperidine; AcOH / toluene; cyclohexane / 3.5 h / Heating

2.1: 18 g / H₂ / Pd/C / ethanol / 3 h / 1034.3 Torr

3.1: 1-methyl-pyrrolidin-2-one / 2 h / 190 °C

4.1: oxalyl chloride; DMF / CH₂Cl₂ / 3 h / Heating

4.2: n-BuNH₂ / CH₂Cl₂ / 1.5 h / Heating

5.1: sodium formate; Pd/C / 2-methoxy-ethanol / 4 h

6.1: 15 percent / NaOEt / dimethylsulfoxide / 20 °C

With piperidine; palladium on activated charcoal; oxalyl dichloride; hydrogen; sodium ethanolate; sodium formate; acetic acid; N,N-dimethyl-formamide; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; 2-methoxy-ethanol; cyclohexane; dimethyl sulfoxide; toluene; 1.1: Knoevenagel reaction;
DOI:10.1021/jm0581718