Ethyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-benzothiazolyl)-2-ethoxycarbonylpropionate

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Chemical Name:Ethyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-benzothiazolyl)-2-ethoxycarbonylpropionate
CAS No.:150611-03-3
Molecular Formula:C₃₁H₃₅N₃O₇S
Molecular Weight:593.701
Hs Code.:

Synonyms:Ethyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-benzothiazolyl)-2-ethoxycarbonylpropionate

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Chemical Property of Ethyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-benzothiazolyl)-2-ethoxycarbonylpropionate

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Technology Process of Ethyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-benzothiazolyl)-2-ethoxycarbonylpropionate

There total 5 articles about Ethyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-benzothiazolyl)-2-ethoxycarbonylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 150610-37-0
2-(bromomethyl)-1,3-benzothiazole-5-carbonitrile

: 150610-51-8
diethyl 2-(4-{[(3S)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl]oxy}phenyl)malonate

: 150611-03-3
Ethyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-benzothiazolyl)-2-ethoxycarbonylpropionate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 72h;
DOI:10.1016/j.bmc.2004.02.032

Reference yield:

: 90418-93-2
2-methyl-1,3-benzothiazole-5-carbonitrile

: 150611-03-3
Ethyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-benzothiazolyl)-2-ethoxycarbonylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 20 percent / N-bromosuccinimide; 2,2'-azobisisobutyronitrile / CCl₄ / Heating; irradiation

2: 100 percent / NaH / tetrahydrofuran / 72 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; In tetrahydrofuran; tetrachloromethane;
DOI:10.1016/j.bmc.2004.02.032

Reference yield:

: 109431-87-0,83220-73-9
(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate

: 150611-03-3
Ethyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-benzothiazolyl)-2-ethoxycarbonylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 48 h / 20 °C

2: 100 percent / NaH / tetrahydrofuran / 72 h / 20 °C

With sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2004.02.032