diethyl 2-(4-{[(3S)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl]oxy}phenyl)malonate

Base Information

• Chemical Name: diethyl 2-(4-{[(3S)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl]oxy}phenyl)malonate
• CAS No.: 150610-51-8
• Molecular Formula: C₂₂H₃₁NO₇
• Molecular Weight: 421.491

Synonyms:diethyl 2-(4-{[(3S)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl]oxy}phenyl)malonate

Chemical Property of diethyl 2-(4-{[(3S)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl]oxy}phenyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-(4-{[(3S)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl]oxy}phenyl)malonate

There total 1 articles about diethyl 2-(4-{[(3S)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl]oxy}phenyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate (109431-87-0,83220-73-9) + diethyl 2-(4-hydroxyphenyl)malonate (80887-79-2) → diethyl 2-(4-{[(3S)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl]oxy}phenyl)malonate (150610-51-8)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 48h;

DOI:10.1016/j.bmc.2004.02.032

Reference yield: 100.0%

2-(bromomethyl)-1,3-benzothiazole-5-carbonitrile (150610-37-0) + diethyl 2-(4-{[(3S)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl]oxy}phenyl)malonate (150610-51-8) → Ethyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-benzothiazolyl)-2-ethoxycarbonylpropionate (150611-03-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 72h;

DOI:10.1016/j.bmc.2004.02.032

Reference yield:

2-(bromomethyl)-1,3-benzothiazole-6-carbonitrile (167979-54-6) + diethyl 2-(4-{[(3S)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl]oxy}phenyl)malonate (150610-51-8) → 2-[4-(1-tert-butoxycarbonyl-pyrrolidin-3-yloxy)-phenyl]-2-(6-cyano-benzothiazol-2-ylmethyl)-malonic acid diethyl ester (167979-41-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 72h;

DOI:10.1016/j.bmc.2004.02.032

upstream raw materials:

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate

diethyl 2-(4-hydroxyphenyl)malonate

Downstream raw materials:

2-[4-(1-tert-butoxycarbonyl-pyrrolidin-3-yloxy)-phenyl]-2-(6-cyano-benzothiazol-2-ylmethyl)-malonic acid diethyl ester

Ethyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-benzothiazolyl)-2-ethoxycarbonylpropionate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 150610-51-8 diethyl 2-(4-{[(3S)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl]oxy}phenyl)malonate

Send

Send

Metric Ton KG G Pound L ML

Send

Send