5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-dihydro-furan-2-one

Base Information

Chemical Name:5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-dihydro-furan-2-one
CAS No.:362483-83-8
Molecular Formula:C₁₇H₂₅ClO₃Si
Molecular Weight:340.922
Hs Code.:

5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-dihydro-furan-2-one

Synonyms:5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-dihydro-furan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-dihydro-furan-2-one

Chemical Property:

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Technology Process of 5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-dihydro-furan-2-one

There total 5 articles about 5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53088-68-9
methyl 3-chlorophenylacetate

: 362483-83-8
5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -60 °C

1.2: tetrahydrofuran / 1 h / -60 - 20 °C

2.1: LiOH / methanol; H₂O / 20 h / 20 °C

3.1: 57percent MCPBA / CHCl₃ / 3 h / Heating

4.1: imidazole / dimethylformamide / 12 h / 20 °C

With 1H-imidazole; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm010155x

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 362483-75-8
3-(3-chloro-phenyl)-5-hydroxymethyl-dihydro-furan-2-one

: 362483-83-8
5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-dihydro-furan-2-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm010155x

Reference yield:

: 1878-65-5
3-chlorophenylacetic acid

: 362483-83-8
5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-phenyl)-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / HCl / 3 h / Heating

2.1: LDA / tetrahydrofuran / 0.5 h / -60 °C

2.2: tetrahydrofuran / 1 h / -60 - 20 °C

3.1: LiOH / methanol; H₂O / 20 h / 20 °C

4.1: 57percent MCPBA / CHCl₃ / 3 h / Heating

5.1: imidazole / dimethylformamide / 12 h / 20 °C

With 1H-imidazole; hydrogenchloride; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm010155x