methyl (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate

Base Information

Chemical Name:methyl (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate
CAS No.:72342-64-4
Molecular Formula:C₁₅H₁₇NO₄
Molecular Weight:275.304
Hs Code.:

Synonyms:methyl (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate

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Technology Process of methyl (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate

There total 12 articles about methyl (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 866395-48-4
(R)-1-diazo-3-phthalimido-4-methylpentan-2-one

: 67-56-1
methanol

: 72342-64-4
methyl (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate

Guidance literature:: With silver benzoate; triethylamine; for 2h; Heating;
DOI:10.1016/j.tet.2005.07.049

Reference yield:

: 67-56-1
methanol

: 1240283-79-7
C₂₀H₁₉NO₃Se

: 72342-64-4
methyl (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate

Guidance literature:: With copper dichloride; In acetonitrile; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.05.143

Reference yield:

: 5115-65-1,6306-53-2,6306-54-3,19506-85-5
(R)-N-phthaloylvaline

: 72342-64-4
methyl (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂; DMF / 20 °C

2: 22.7 g / diethyl ether; toluene / 0 °C

3: 72 percent / PhCO₂Ag; Et₃N / 2 h / Heating

With thionyl chloride; silver benzoate; triethylamine; N,N-dimethyl-formamide; In diethyl ether; toluene; 3: Wolff rearrangement;
DOI:10.1016/j.tet.2005.07.049