N²-[4-hydroxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N¹-methylamide

Base Information

Chemical Name:N²-[4-hydroxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N¹-methylamide
CAS No.:198421-47-5
Molecular Formula:C₂₁H₃₂N₂O₄S
Molecular Weight:408.562
Hs Code.:

N<sup>2</sup>-[4-hydroxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N<sup>1</sup>-methylamide

Synonyms:N²-[4-hydroxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N¹-methylamide

Suppliers and Price of N²-[4-hydroxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N¹-methylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N²-[4-hydroxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N¹-methylamide

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Technology Process of N²-[4-hydroxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N¹-methylamide

There total 5 articles about N²-[4-hydroxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N¹-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 198421-46-4
N²-[4-tert-butyloxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N¹-methylamide

: 198421-47-5
N²-[4-hydroxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N¹-methylamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃;
DOI:10.1021/jm990377j

Reference yield:

: 882-33-7
diphenyldisulfane

: 198421-47-5
N²-[4-hydroxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N¹-methylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 °C

1.2: 43 percent / tetrahydrofuran; hexane / 2.5 h / -78 - 20 °C

2.1: 78 percent / HOBT; N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; DMAP / dimethylformamide / 20 °C

3.1: 100 percent / TFA / CH₂Cl₂ / 0 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Condensation / 2.1: Condensation / 3.1: Hydrolysis;
DOI:10.1021/jm990377j

Reference yield:

: 89226-12-0
(S)-2-amino-N,3,3-trimethylbutanamide

: 198421-47-5
N²-[4-hydroxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N¹-methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / HOBT; N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; DMAP / dimethylformamide / 20 °C

2: 100 percent / TFA / CH₂Cl₂ / 0 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: Hydrolysis;
DOI:10.1021/jm990377j