1-[4-methyl-6-(isopropylamino)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Base Information

Chemical Name:1-[4-methyl-6-(isopropylamino)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide
CAS No.:1439923-15-5
Molecular Formula:C₂₁H₂₇F₃N₆O
Molecular Weight:436.48
Hs Code.:

Synonyms:1-[4-methyl-6-(isopropylamino)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Suppliers and Price of 1-[4-methyl-6-(isopropylamino)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[4-methyl-6-(isopropylamino)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[4-methyl-6-(isopropylamino)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

There total 5 articles about 1-[4-methyl-6-(isopropylamino)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1141895-74-0
1-[4-chloro-6-methyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

: 75-31-0
isopropylamine

: 1439923-15-5
1-[4-methyl-6-(isopropylamino)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Guidance literature:: With methanol; ammonia; N-ethyl-N,N-diisopropylamine; In water; acetonitrile; at 80 ℃;
DOI:10.1016/j.bmcl.2013.04.019

Reference yield:

: 3048-01-9
o-trifluoromethylbenzylamine

: 1439923-15-5
1-[4-methyl-6-(isopropylamino)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 10 °C

2: trifluoroacetic acid / 1 h / 0 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; ammonia; methanol / acetonitrile; water / 80 °C

With methanol; dmap; ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmcl.2013.04.019

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1439923-15-5
1-[4-methyl-6-(isopropylamino)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 10 °C

2: trifluoroacetic acid / 1 h / 0 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; ammonia; methanol / acetonitrile; water / 80 °C

With methanol; dmap; ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmcl.2013.04.019