3-(3-isopropyl-1H-1,2,4-triazol-5-yl)-4-((tetrahydro-2H-pyran-4-yl)oxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

Base Information

• Chemical Name: 3-(3-isopropyl-1H-1,2,4-triazol-5-yl)-4-((tetrahydro-2H-pyran-4-yl)oxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine
• CAS No.: 1367875-42-0
• Molecular Formula: C₃₅H₃₄N₆O₂
• Molecular Weight: 570.694
• Mol file: 1367875-42-0.mol

Synonyms:3-(3-isopropyl-1H-1,2,4-triazol-5-yl)-4-((tetrahydro-2H-pyran-4-yl)oxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

Chemical Property of 3-(3-isopropyl-1H-1,2,4-triazol-5-yl)-4-((tetrahydro-2H-pyran-4-yl)oxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-isopropyl-1H-1,2,4-triazol-5-yl)-4-((tetrahydro-2H-pyran-4-yl)oxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

There total 7 articles about 3-(3-isopropyl-1H-1,2,4-triazol-5-yl)-4-((tetrahydro-2H-pyran-4-yl)oxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-iodo-4-((tetrahydro-2H-pyran-4-yl)oxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine (1367874-63-2) + 2-methylpropanimidamide hydrochloride (22007-68-7) + hydrazine hydrate (7803-57-8,79785-97-0) → 3-(3-isopropyl-1H-1,2,4-triazol-5-yl)-4-((tetrahydro-2H-pyran-4-yl)oxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine (1367875-42-0)

Guidance literature:

3-iodo-4-((tetrahydro-2H-pyran-4-yl)oxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine; 2-methylpropanimidamide hydrochloride; With triethylamine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; at 80 ℃; for 2.5h; Inert atmosphere;

hydrazine hydrate; In acetic acid; at 0 - 20 ℃; for 1h;

Reference yield:

carbon monoxide (201230-82-2) + 3-iodo-4-((tetrahydro-2H-pyran-4-yl)oxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine (1367874-63-2) + 2-methylpropanimidamide hydrochloride (22007-68-7) → 3-(3-isopropyl-1H-1,2,4-triazol-5-yl)-4-((tetrahydro-2H-pyran-4-yl)oxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine (1367875-42-0)

Guidance literature:

carbon monoxide; 3-iodo-4-((tetrahydro-2H-pyran-4-yl)oxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine; 2-methylpropanimidamide hydrochloride; With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

With hydrazine hydrate; acetic acid; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

DOI:10.1016/j.bmcl.2018.10.017

Reference yield:

2,4-dichloro-3-pyridine Carboxaldehyde (134031-24-6) → 3-(3-isopropyl-1H-1,2,4-triazol-5-yl)-4-((tetrahydro-2H-pyran-4-yl)oxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine (1367875-42-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrazine hydrate / 1,2-dimethoxyethane / 20 - 75 °C

2.1: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 19 h / 20 °C

4.1: sodium hydride / 1,4-dioxane; mineral oil / 3 h / 20 °C

4.2: 2 h / 190 °C / Microwave irradiation

5.1: triethylamine / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 2.5 h / 80 °C / Inert atmosphere

5.2: 1 h / 0 - 20 °C

With iodine; sodium hydride; hydrazine hydrate; triethylamine; potassium hydroxide; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

2,4-dichloro-3-pyridine Carboxaldehyde

3-iodo-4-((tetrahydro-2H-pyran-4-yl)oxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

2-methylpropanimidamide hydrochloride

hydrazine hydrate