2-(2-Methoxyphenoxy)acetamide

Base Information

• Chemical Name: 2-(2-Methoxyphenoxy)acetamide
• CAS No.: 183427-87-4
• Molecular Formula: C9H11 N O3
• Molecular Weight: 181.191
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID20352331
• Wikidata: Q82129403
• Mol file: 183427-87-4.mol

Synonyms:2-(2-methoxyphenoxy)acetamide;183427-87-4;Acetamide, 2-(2-methoxyphenoxy)-;Maybridge1_008789;Oprea1_103009;Oprea1_388657;SCHEMBL5520675;2-(2-methoxyphenoxy) acetamide;HMS566H11;DTXSID20352331;MFCD00834989;STK023938;AKOS000490809;TS-00206;CS-0182661;FT-0608488;E78012;A812776;AC-907/34127021;Z19753985

Chemical Property of 2-(2-Methoxyphenoxy)acetamide

Chemical Property:

• Vapor Pressure: 2.69E-05mmHg at 25°C
• Melting Point: 142°C
• Refractive Index: 1.53
• Boiling Point: 357.7°Cat760mmHg
• Flash Point: 198.2°C
• PSA: 61.55000
• Density: 1.17g/cm³
• LogP: 1.25960
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 181.07389321
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Methoxyphenoxy)acetamide 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1OCC(=O)N

Technology Process of 2-(2-Methoxyphenoxy)acetamide

There total 6 articles about 2-(2-Methoxyphenoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-methoxy-phenol (90-05-1) + Chloroacetamide (79-07-2) → 2-(2-methoxyphenoxy)acetamide (183427-87-4)

Guidance literature:

2-methoxy-phenol; With sodium ethanolate; In ethanol; for 0.5h; Heating;

Chloroacetamide; With potassium iodide; In ethanol; Heating;

DOI:10.1021/jm021078o

Reference yield: 77.0%

→ 2-(2-methoxyphenoxy)acetamide (183427-87-4)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; In water; at 80 ℃; for 4h;

Reference yield:

ethyl 2-(2-methoxyphenoxy)acetate (13078-21-2) → 2-(2-methoxyphenoxy)acetamide (183427-87-4)

Guidance literature:

With ammonia;

DOI:10.1002/clc.4960240303

upstream raw materials:

ethyl 2-(2-methoxyphenoxy)acetate

potassium guaiacolate

Chloroacetamide

sodium 2-methoxyphenolate

Downstream raw materials:

2-(2-methoxy-phenoxy)-ethylamine

2-(3-Aminopropyl)-1-methoxybenzene