N-[5-(2-amino-1-{[4-(4-morpholinyl)phenyl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Base Information

Chemical Name:N-[5-(2-amino-1-{[4-(4-morpholinyl)phenyl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide
CAS No.:1416335-35-7
Molecular Formula:C₃₀H₂₈F₂N₆O₄S
Molecular Weight:606.653
Hs Code.:

Synonyms:N-[5-(2-amino-1-{[4-(4-morpholinyl)phenyl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

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Chemical Property of N-[5-(2-amino-1-{[4-(4-morpholinyl)phenyl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

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Technology Process of N-[5-(2-amino-1-{[4-(4-morpholinyl)phenyl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

There total 7 articles about N-[5-(2-amino-1-{[4-(4-morpholinyl)phenyl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1416335-35-7
N-[5-(2-amino-1-{[4-(4-morpholinyl)phenyl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 20 °C

2: sodium dithionite / water; tetrahydrofuran

3: acetonitrile; water; methanol / 16 h

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 1 h / 90 °C

With sodium dithionite; potassium acetate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; 4: Suzuki Coupling;

Reference yield:

: 214759-74-7
1-(4-morpholin-4-ylphenyl)methanamine

: 1416335-35-7
N-[5-(2-amino-1-{[4-(4-morpholinyl)phenyl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 20 °C

2: sodium dithionite / water; tetrahydrofuran

3: acetonitrile; water; methanol / 16 h

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 1 h / 90 °C

With sodium dithionite; potassium acetate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; 4: Suzuki Coupling;

Reference yield:

: 152684-30-5
5-bromo-2-methoxy-3-nitropyridine

: 1416335-35-7
N-[5-(2-amino-1-{[4-(4-morpholinyl)phenyl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: tin(II) chloride dihdyrate / acetic anhydride / 3 h / Reflux

2: pyridine / 20 h / 20 °C

3: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux; Inert atmosphere

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 1 h / 90 °C

With pyridine; tin(II) chloride dihdyrate; potassium acetate; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; acetic anhydride; N,N-dimethyl-formamide; 3: Suzuki Coupling / 4: Suzuki Coupling;