CPPG

Base Information

Chemical Name:CPPG
CAS No.:183364-82-1
Molecular Formula:C₁₁H₁₄NO₅P
Molecular Weight:271.21
Hs Code.:
Mol file:183364-82-1.mol

Synonyms:CPPG;a-Cyclopropyl-4-phosphonophenylglycine

Suppliers and Price of CPPG

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
CPPG
10mg
$ 438.00

TRC
rac-CPPG
10mg
$ 130.00

Tocris
CPPG ≥98%(HPLC)
5
$ 103.00

Tocris
CPPG ≥98%(HPLC)
25
$ 389.00

Sigma-Aldrich
CPPG ≥98% (HPLC)
5mg
$ 106.00

Sigma-Aldrich
CPPG ≥98% (HPLC)
25mg
$ 411.00

ApexBio Technology
CPPG
25mg
$ 566.00

ApexBio Technology
CPPG
5mg
$ 150.00

Total 7 raw suppliers

Chemical Property of CPPG

Chemical Property:

PSA：130.66000
LogP:0.83850
Storage Temp.:Store at RT
Solubility.:H2O: >5mg/mL

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

CPPG ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Uses (RS)-CPPG is the most potent group II/III mGluR antagonist.

Technology Process of CPPG

There total 10 articles about CPPG which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 323192-84-3
(S)-α-cyclopropyl-4-(ethylphosphono)phenylglycine

: 183364-82-1
(S)-α-cyclopropyl-4-phosphonophenylglycine

Guidance literature:: With hydrogenchloride; at 80 ℃; for 72h;
DOI:10.1021/jo0013711

Reference yield:

: 323192-76-3
(2S,4R)-2-phenyl-4-((4-phenylmethoxy)phenyl)-5-oxo-3-oxazolidinecarboxylic acid methyl ester

: 183364-82-1
(S)-α-cyclopropyl-4-phosphonophenylglycine

Guidance literature:: Multi-step reaction with 9 steps

1.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C

1.2: 88 percent / 0.75 h / -78 °C

2.1: 54 percent / LiOH / tetrahydrofuran; H₂O / 20 °C

3.1: 80 percent

4.1: 23 percent / Pd(acac)2 / diethyl ether / 10 h / 20 °C

5.1: H₂ / Pd/C / methanol / 3 h / 20 °C

6.1: 3.4 g / Et₃N / CH₂Cl₂ / 2 h / -30 °C

7.1: 87 percent / Et₃N / Pd(PPh₃)4 / 3 h / Heating

8.1: 99 percent / 2N NaOH / 48 h / Heating

9.1: 99 percent / 2N HCl / 72 h / 80 °C

With hydrogenchloride; lithium hydroxide; sodium hydroxide; hydrogen; sodium hexamethyldisilazane; triethylamine; palladium(II) acetylacetonate; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/jo0013711

Reference yield:

: 323192-77-4
(2R,4R)-2-phenyl-4-(2-bromoethyl)-4-((4-phenylmethoxy)phenyl)-5-oxo-3-oxazolidinecarboxylic acid methyl ester

: 183364-82-1
(S)-α-cyclopropyl-4-phosphonophenylglycine

Guidance literature:: Multi-step reaction with 8 steps

1: 54 percent / LiOH / tetrahydrofuran; H₂O / 20 °C

2: 80 percent

3: 23 percent / Pd(acac)2 / diethyl ether / 10 h / 20 °C

4: H₂ / Pd/C / methanol / 3 h / 20 °C

5: 3.4 g / Et₃N / CH₂Cl₂ / 2 h / -30 °C

6: 87 percent / Et₃N / Pd(PPh₃)4 / 3 h / Heating

7: 99 percent / 2N NaOH / 48 h / Heating

8: 99 percent / 2N HCl / 72 h / 80 °C

With hydrogenchloride; lithium hydroxide; sodium hydroxide; hydrogen; triethylamine; palladium(II) acetylacetonate; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/jo0013711