5-(2-hydroxyphenethyl)-2-methyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole

Base Information

• Chemical Name: 5-(2-hydroxyphenethyl)-2-methyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole
• CAS No.: 113549-31-8
• Molecular Formula: C₂₄H₂₃NO₄S
• Molecular Weight: 421.517
• Mol file: 113549-31-8.mol

Synonyms:5-(2-hydroxyphenethyl)-2-methyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole

Chemical Property of 5-(2-hydroxyphenethyl)-2-methyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-hydroxyphenethyl)-2-methyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole

There total 1 articles about 5-(2-hydroxyphenethyl)-2-methyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dimethyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole (107402-99-3) + benzaldehyde (100-52-7) → 5-(2-hydroxyphenethyl)-2-methyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole (113549-31-8)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg C, 1 h, 2.) 0 deg C, 1 h;

DOI:10.1039/P19880002639

Reference yield: 98.0%

5-(2-hydroxyphenethyl)-2-methyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole (113549-31-8) → 1,5-diphenyl-1-hydroxy-4-(phenylsulfonyl)-4-penten-3-one (113549-32-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1021/jo00245a021

Reference yield: 95.0%

methanesulfonyl chloride (124-63-0) + 5-(2-hydroxyphenethyl)-2-methyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole (113549-31-8) → Methanesulfonic acid 2-(4-benzenesulfonyl-2-methyl-3-phenyl-2,3-dihydro-isoxazol-5-yl)-1-phenyl-ethyl ester (113549-17-0)

Guidance literature:

With triethylamine; In dichloromethane; 0 deg C, 2 h, RT, 45 min;

DOI:10.1039/P19880002639

upstream raw materials:

2,5-dimethyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole

benzaldehyde

Downstream raw materials:

Methanesulfonic acid 2-(4-benzenesulfonyl-2-methyl-3-phenyl-2,3-dihydro-isoxazol-5-yl)-1-phenyl-ethyl ester

1,5-diphenyl-1-hydroxy-4-(phenylsulfonyl)-4-penten-3-one

1,5-diphenyl-2-(phenylsulfonyl)-1,4-pentadien-3-one

2,6-diphenyl-3-(phenylsulfonyl)tetrahydro-γ-pyranone

Refernces

• 1、 Padwa, Albert,Chiacchio, Ugo,Kline, Donald N.,Perumattam, John. "Peracid Oxidation of 4-Isoxazolines as a Method for the Preparation of α, β-Unsaturated Carbonyl Compounds". . p. 2238 - 2245. Retrieved 2007/10/02.