<(S)-1-Benzyl-2-<(R)-2-<2(4-tert.-butyldimethylsilyloxy3-methoxyphenyl)-ethenyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat

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Chemical Name:<(S)-1-Benzyl-2-<(R)-2-<2(4-tert.-butyldimethylsilyloxy3-methoxyphenyl)-ethenyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat
CAS No.:132255-86-8
Molecular Formula:C₃₃H₄₇NO₅Si
Molecular Weight:565.825
Hs Code.:

Synonyms:<(S)-1-Benzyl-2-<(R)-2-<2(4-tert.-butyldimethylsilyloxy3-methoxyphenyl)-ethenyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat

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Chemical Property of <(S)-1-Benzyl-2-<(R)-2-<2(4-tert.-butyldimethylsilyloxy3-methoxyphenyl)-ethenyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat

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Technology Process of <(S)-1-Benzyl-2-<(R)-2-<2(4-tert.-butyldimethylsilyloxy3-methoxyphenyl)-ethenyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat

There total 6 articles about <(S)-1-Benzyl-2-<(R)-2-<2(4-tert.-butyldimethylsilyloxy3-methoxyphenyl)-ethenyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 132255-85-7,132340-24-0
<(S)-1-Benzyl-2-<(R)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2(R)-hydroxyethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat und <(S)-1-Benzyl-2-<(R)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2(S)-hydroxyethyl>-pyrrolidino ...

: 132255-86-8
<(S)-1-Benzyl-2-<(R)-2-<2(4-tert.-butyldimethylsilyloxy3-methoxyphenyl)-ethenyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; 1) 30 min, 15 deg C, 2) 40 h, 0 deg C;
DOI:10.1002/ardp.19903231208

Reference yield:

: 132255-78-8
4-(tert.-Butyldimethylsilyloxy)-3-methoxyacetophenon

: 132255-86-8
<(S)-1-Benzyl-2-<(R)-2-<2(4-tert.-butyldimethylsilyloxy3-methoxyphenyl)-ethenyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / Tetrabutylammoniumfluoride / tetrahydrofuran / 1) -78 deg C, 3 h, 2) to 0 deg C, 1 h, 3) 0 deg C, 2 h

2: 1) TiCl₄ / 1) CH₂Cl₂, 0 deg C, 45 min, 2) 0deg C, 16h

3: 81.7 percent / Li / tetrahydrofuran / 16 h / 0 °C

4: 72 percent / Triethylamin, Methansulfonsaeurechlorid / CH₂Cl₂ / 1) 30 min, 15 deg C, 2) 40 h, 0 deg C

With tetrabutyl ammonium fluoride; titanium tetrachloride; methanesulfonyl chloride; lithium tri-t-butoxyaluminum hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ardp.19903231208

Reference yield:

: 132255-68-6
1-(tert.-Butyldimethylsilyloxy)-2-methoxy-4-(1-trimethylsilyloxyethenyl)-benzol

: 132255-86-8
<(S)-1-Benzyl-2-<(R)-2-<2(4-tert.-butyldimethylsilyloxy3-methoxyphenyl)-ethenyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat

Guidance literature:: Multi-step reaction with 3 steps

1: 1) TiCl₄ / 1) CH₂Cl₂, 0 deg C, 45 min, 2) 0deg C, 16h

2: 81.7 percent / Li / tetrahydrofuran / 16 h / 0 °C

3: 72 percent / Triethylamin, Methansulfonsaeurechlorid / CH₂Cl₂ / 1) 30 min, 15 deg C, 2) 40 h, 0 deg C

With titanium tetrachloride; methanesulfonyl chloride; lithium tri-t-butoxyaluminum hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ardp.19903231208