3'-deoxy-5'-O-dimethoxytrityl-3'-S-(5-nitropyridyl-2-disulfanyl)thymidine

Base Information

• Chemical Name: 3'-deoxy-5'-O-dimethoxytrityl-3'-S-(5-nitropyridyl-2-disulfanyl)thymidine
• CAS No.: 195967-03-4
• Molecular Formula: C₃₆H₃₄N₄O₈S₂
• Molecular Weight: 714.82
• Mol file: 195967-03-4.mol

Synonyms:3'-deoxy-5'-O-dimethoxytrityl-3'-S-(5-nitropyridyl-2-disulfanyl)thymidine

Chemical Property of 3'-deoxy-5'-O-dimethoxytrityl-3'-S-(5-nitropyridyl-2-disulfanyl)thymidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-deoxy-5'-O-dimethoxytrityl-3'-S-(5-nitropyridyl-2-disulfanyl)thymidine

There total 3 articles about 3'-deoxy-5'-O-dimethoxytrityl-3'-S-(5-nitropyridyl-2-disulfanyl)thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

5,5'-dinitro-2,2'-disulfanediyl-bis-pyridine (2127-10-8) + 3'-mercapto-5'-O-DMT-3'-deoxythymidine (123126-01-2) → 3'-deoxy-5'-O-dimethoxytrityl-3'-S-(5-nitropyridyl-2-disulfanyl)thymidine (195967-03-4)

Guidance literature:

In dichloromethane;

DOI:10.1080/07328319708006228

Reference yield:

1-(2'-deoxy-3'-O-mesyl-5'-O-4,4'-dimethoxytrityl-β-D-threo-pentofuranosyl)-thymine (143527-01-9) → 3'-deoxy-5'-O-dimethoxytrityl-3'-S-(5-nitropyridyl-2-disulfanyl)thymidine (195967-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / dimethylformamide / 100 °C

2: 1.) NaOH, 2.) AcOH / 1.) EtOH

3: 50 percent / CH₂Cl₂

With sodium hydroxide; acetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1080/07328319708006228

Reference yield:

Thiobenzoic acid S-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester (143527-02-0) → 3'-deoxy-5'-O-dimethoxytrityl-3'-S-(5-nitropyridyl-2-disulfanyl)thymidine (195967-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaOH, 2.) AcOH / 1.) EtOH

2: 50 percent / CH₂Cl₂

With sodium hydroxide; acetic acid; In dichloromethane;

DOI:10.1080/07328319708006228

upstream raw materials:

5,5'-dinitro-2,2'-disulfanediyl-bis-pyridine

3'-mercapto-5'-O-DMT-3'-deoxythymidine

1-(2'-deoxy-3'-O-mesyl-5'-O-4,4'-dimethoxytrityl-β-D-threo-pentofuranosyl)-thymine

Thiobenzoic acid S-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

Downstream raw materials:

C₄₇H₅₈N₄O₁₀S₂Si

C₄₁H₄₄N₄O₁₀S₂