methyl (S,S)-1-(4-nitrobenzenesulfonyl)-6-prop-2-ynyl-1,2,3,6-tetrahydropyridine-2-carboxylate

Base Information

Chemical Name:methyl (S,S)-1-(4-nitrobenzenesulfonyl)-6-prop-2-ynyl-1,2,3,6-tetrahydropyridine-2-carboxylate
CAS No.:282527-11-1
Molecular Formula:C₁₆H₁₆N₂O₆S
Molecular Weight:364.379
Hs Code.:

Synonyms:methyl (S,S)-1-(4-nitrobenzenesulfonyl)-6-prop-2-ynyl-1,2,3,6-tetrahydropyridine-2-carboxylate

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Chemical Property of methyl (S,S)-1-(4-nitrobenzenesulfonyl)-6-prop-2-ynyl-1,2,3,6-tetrahydropyridine-2-carboxylate

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Technology Process of methyl (S,S)-1-(4-nitrobenzenesulfonyl)-6-prop-2-ynyl-1,2,3,6-tetrahydropyridine-2-carboxylate

There total 3 articles about methyl (S,S)-1-(4-nitrobenzenesulfonyl)-6-prop-2-ynyl-1,2,3,6-tetrahydropyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 53915-69-8
allenyltributylstannane

: 282527-08-6
methyl (2S)-6-benzyloxy-1-(4-nitrobenzenesulfonyl)-1,2,3,6-tetrahydropyridine-2-carboxylate

: 282527-11-1
methyl (S,S)-1-(4-nitrobenzenesulfonyl)-6-prop-2-ynyl-1,2,3,6-tetrahydropyridine-2-carboxylate

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -78 - 20 ℃;
DOI:10.1039/b001253j

Reference yield:

: methyl (S)-2-(4-nitrobenzenesulfonylamino)pent-4-enoate

: 282527-11-1
methyl (S,S)-1-(4-nitrobenzenesulfonyl)-6-prop-2-ynyl-1,2,3,6-tetrahydropyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / Et₃N / Pd(OAc)2/dppp / acetonitrile / 16 h / 20 °C

2: 89 percent / RuCl₂[PCy₃]2[=CHPh] / CH₂Cl₂ / 16 h / 20 °C

3: 75 percent / BF₃*OEt₂ / CH₂Cl₂ / 3 h / -78 °C

With boron trifluoride diethyl etherate; triethylamine; palladium diacetate; Grubbs catalyst first generation; 1,3-bis-(diphenylphosphino)propane; In dichloromethane; acetonitrile;
DOI:10.1002/1615-4169(200208)344:6/7<736::AID-ADSC736>3.0.CO;2-8

Reference yield:

: 282527-06-4
methyl 2-[(1-benzyloxyallyl)-(4-nitrobenzenesulfonyl)amino]-(S)-pent-4-enoate

: 282527-11-1
methyl (S,S)-1-(4-nitrobenzenesulfonyl)-6-prop-2-ynyl-1,2,3,6-tetrahydropyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / RuCl₂[PCy₃]2[=CHPh] / CH₂Cl₂ / 16 h / 20 °C

2: 75 percent / BF₃*OEt₂ / CH₂Cl₂ / 3 h / -78 °C

With boron trifluoride diethyl etherate; Grubbs catalyst first generation; In dichloromethane;
DOI:10.1002/1615-4169(200208)344:6/7<736::AID-ADSC736>3.0.CO;2-8