2,2-bis(4-chlorophenyl)-5-Methyl-1,3-dioxane-5-carboxylic acid

Base Information

Chemical Name:2,2-bis(4-chlorophenyl)-5-Methyl-1,3-dioxane-5-carboxylic acid
CAS No.:1296664-72-6
Molecular Formula:C₁₈H₁₆Cl₂O₄
Molecular Weight:367.229
Hs Code.:
Mol file:1296664-72-6.mol

Synonyms:2,2-bis(4-chloro phenyl)-5-methyl-1,3-dioxane-5-carboxylic acid

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Chemical Property of 2,2-bis(4-chlorophenyl)-5-Methyl-1,3-dioxane-5-carboxylic acid

Chemical Property:

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Technology Process of 2,2-bis(4-chlorophenyl)-5-Methyl-1,3-dioxane-5-carboxylic acid

There total 2 articles about 2,2-bis(4-chlorophenyl)-5-Methyl-1,3-dioxane-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.54%

: 4767-03-7
2,2-bis(hydroxymethyl)propionic acid

: 6861-53-6
4,4’-dichlorobenzophenone dimethyl acetal

: 1296664-72-6
2,2-bis(4-chloro phenyl)-5-methyl-1,3-dioxane-5-carboxylic acid

Guidance literature:: 2,2-bis(hydroxymethyl)propionic acid; toluene-4-sulfonic acid; In toluene; at 20 ℃;

4,4’-dichlorobenzophenone dimethyl acetal; In toluene; Reflux;

Reference yield:

: 90-98-2
4,4'-Dichlorobenzophenone

: 1296664-72-6
2,2-bis(4-chloro phenyl)-5-methyl-1,3-dioxane-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: perchloric acid / methanol / 7.5 h / 25 - 30 °C / Reflux

2: toluene-4-sulfonic acid / toluene / 20 °C / Reflux

perchloric acid; toluene-4-sulfonic acid; In methanol; toluene;

Reference yield:

: 1296664-72-6
2,2-bis(4-chloro phenyl)-5-methyl-1,3-dioxane-5-carboxylic acid

: 162635-04-3,343261-52-9
temsirolimus

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 5 °C / Inert atmosphere

2: dmap / toluene

3: sulfuric acid / water; tetrahydrofuran / 40.25 h / 0 - 30 °C

With sulfuric acid; triethylamine; dmap; In tetrahydrofuran; dichloromethane; water; toluene;