6861-53-6

Upstream product

• 67-56-1 methanol 
• 5463-11-6 4,4'-dichlorobenzophenone hydrazone 
• 7457-25-2 bis-(4-chlorophenyl)-dichloromethane 
• 124-41-4 sodium methylate 
• 90-98-2 4,4'-Dichlorobenzophenone 
• 149-73-5 trimethyl orthoformate 
• 21367-49-7 4,4'-dichloro-benzophenone 4-phenyl-semicarbazone 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 1296664-72-6 2,2-bis(4-chloro phenyl)-5-methyl-1,3-dioxane-5-carboxylic acid 
• 1296664-73-7 C₆₉H₉₃Cl₂NO₁₆ 
• 1296664-95-3 C₂₅H₁₇Cl₅O₅ 
• 161368-10-1 Methyl (2,2-di[4-chlorophenyl]-1,3-benzodioxolan-5-yl)acetate 

Relevant academic research and scientific papers

Highly efficient acetalization of carbonyl compounds catalyzed by anilin-aldehyde resin salts

A mild procedures for the syntheses of ethylene acetals and dimethyl acetals from the corresponding aldehydes and ketones catalyzed by 1mol% of anilinealdehyde resin salts are described. This method is also useful for the synthesis of dimethyl acetals of diaryl ketones.

Anodic cleavage of several ketone N-phenylsemicarbazones into methyl N-phenylcarbamate and the corresponding dimethyl acetals

Several ketone N-phenylsemicarbazones were electrooxidized in the presence of potassium iodide and a base using methanol as the solvent to give nearly commensurate amounts of methyl N-phenylcarbamate and the corresponding dimethyl acetals. Continuous evolution of gaseous nitrogen was observed from the anolyte during the electrooxidation. The reactions were carried out under very mild reaction conditions and are presumed to proceed through a four-electron oxidation process, in which the iodide ion plays an important role as an electron carrier.

PROCESS FOR THE PREPARATION OF RAPAMYCIN DERIVATIVES

The invention relates to processes for the preparation of compound of CCI-779 having the Formula (I), which is useful as an antineoplastic agent. The invention further relates to certain novel intermediates useful in the preparation of compound of CCI-779 and processes for their preparation. The invention also relates to pharmaceutical compositions that include the compound of CCI-779, prepared according to the processes disclosed herein.

PROCESS FOR THE PREPARATION OF RAPAMYCIN DERIVATIVES

The invention relates to processes for the preparation of compound of CCI-779 having the Formula (I), which is useful as an antineoplastic agent. The invention further relates to certain novel intermediates useful in the preparation of compound of CCI-779 and processes for their preparation. The invention also relates to pharmaceutical compositions that include the compound of CCI-779, prepared according to the processes disclosed herein.

Iron(III) tosylate in the preparation of dimethyl and diethyl acetals from ketones and β-keto enol ethers from cyclic β-diketones

An efficient method for conversion of ketones to their corresponding dimethyl and diethyl acetals and of cyclic β-diketones into β-keto enol ethers using Fe(OTs)3 as a catalyst is described. Copyright Taylor & Francis Group, LLC.

Simple method for the preparation of dimethyl acetals from ketones with montmorillonite K 10 and p-toluenesulfonic acid

A simple method for conversion of ketones to their corresponding dimethyl acetals using montmorillonite K 10 and p-toluenesulfonic acid as acidic cocatalysts under very mild reaction conditions is described. Copyright Taylor & Francis Group, LLC.

A simple and versatile method for the synthesis of acetals from aldehydes and ketones using bismuth triflate

Acetals are obtained in good yields by treatment of aldehydes and ketones with trialkyl orthoformate and the corresponding alcohol in the presence of 0.1 mol % Bi(OTf)3·4H2O. A simple procedure for the formation of acetals of diaryl ketones has also been developed. The conversion of carbonyl compounds to the corresponding 1,3-dioxolane using ethylene glycol is also catalyzed by Bi(OTf)3· 4H2O (1 mol %). Two methods, both of which avoid the use of benzene, have been developed.

Indole derivatives as 5-α-reductase-1-inhibitors

A compound of formula (I): STR1 and the pharmaceutically acceptable base salts thereof, wherein: R is CO2 R12 where R12 is H or a biolabile ester-forming group, or R is tetrazol-5-yl, and either (a) R1 is STR2 a

Indole derivatives as steroid 5α-reductase inhibitors

A method of treatment of a human to inhibit a steroid 5α-reductase, particularly a testosterone 5α-reductase, which comprises treating said human with an effective amount of a compound of the formula (I) STR1 or a pharmaceutically acceptable base salt the

Indole derivatives as steroid 5α-reductase inhibitors

Compounds of formula (I) STR1 and the pharmaceutically acceptable base salts thereof, wherein R is --CO2 H or tetrazol-5 yl; R1 is C3 -C8 alkyl optionally substituted by fluoro; and R2 is C2/sub