2-(5-isobutyl-[1,1'-biphenyl]-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Base Information

Chemical Name:2-(5-isobutyl-[1,1'-biphenyl]-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide
CAS No.:1346459-83-3
Molecular Formula:C₂₆H₂₂F₇NO
Molecular Weight:497.456
Hs Code.:

Synonyms:2-(5-isobutyl-[1,1'-biphenyl]-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

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Chemical Property of 2-(5-isobutyl-[1,1'-biphenyl]-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

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Technology Process of 2-(5-isobutyl-[1,1'-biphenyl]-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

There total 7 articles about 2-(5-isobutyl-[1,1'-biphenyl]-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1346459-76-4
2-(4-isobutylphenyl)-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]propanamide

: 780-69-8
triethoxyphenylsilane

: 1346459-83-3
2-(5-isobutyl-[1,1'-biphenyl]-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: With 7-( tert-butyl)-2,5-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]quinoline; palladium diacetate; silver fluoride; potassium hydrogencarbonate; In 1,4-dioxane; at 20 - 110 ℃; for 18h; Sealed tube;
DOI:10.1021/jacs.5b00890

Reference yield: 71.0%

: 1346459-76-4
2-(4-isobutylphenyl)-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]propanamide

: 24388-23-6
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole

: 1346459-83-3
2-(5-isobutyl-[1,1'-biphenyl]-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

: 1346459-85-5
2-(5-isobutylbiphenyl-2-yl)-3-phenyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: With water; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone; In tert-Amyl alcohol; at 100 ℃; for 12h; Inert atmosphere;
DOI:10.1246/cl.2011.1004

Reference yield:

: 71381-91-4,114978-05-1,115588-20-0,34715-60-1
(+/-)-2-(4-isobutylphenyl)propanoyl chloride

: 1346459-83-3
2-(5-isobutyl-[1,1'-biphenyl]-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 12.5 h / 20 °C / Reflux

2: palladium diacetate; silver fluoride; potassium hydrogencarbonate; 7-( tert-butyl)-2,5-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]quinoline / 1,4-dioxane / 18 h / 20 - 110 °C / Sealed tube

With 7-( tert-butyl)-2,5-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]quinoline; palladium diacetate; silver fluoride; potassium hydrogencarbonate; In 1,4-dioxane; toluene;
DOI:10.1021/jacs.5b00890