2-(5-isobutylbiphenyl-2-yl)-3-phenyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Base Information

Chemical Name:2-(5-isobutylbiphenyl-2-yl)-3-phenyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide
CAS No.:1346459-85-5
Molecular Formula:C₃₂H₂₆F₇NO
Molecular Weight:573.553
Hs Code.:

Synonyms:2-(5-isobutylbiphenyl-2-yl)-3-phenyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(5-isobutylbiphenyl-2-yl)-3-phenyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

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Technology Process of 2-(5-isobutylbiphenyl-2-yl)-3-phenyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

There total 4 articles about 2-(5-isobutylbiphenyl-2-yl)-3-phenyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1346459-76-4
2-(4-isobutylphenyl)-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]propanamide

: 24388-23-6
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole

: 1346459-83-3
2-(5-isobutyl-[1,1'-biphenyl]-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

: 1346459-85-5
2-(5-isobutylbiphenyl-2-yl)-3-phenyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: With water; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone; In tert-Amyl alcohol; at 100 ℃; for 12h; Inert atmosphere;
DOI:10.1246/cl.2011.1004

Reference yield:

: 15687-27-1,58560-75-1
ibuprofen

: 1346459-83-3
2-(5-isobutyl-[1,1'-biphenyl]-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

: 1346459-85-5
2-(5-isobutylbiphenyl-2-yl)-3-phenyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 0 - 20 °C / Inert atmosphere

2: toluene / 28 h / 20 °C / Reflux

3: water; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone / tert-Amyl alcohol / 12 h / 100 °C / Inert atmosphere

With thionyl chloride; water; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone; In tert-Amyl alcohol; toluene;
DOI:10.1246/cl.2011.1004

Reference yield:

: 434-64-0
perfluorotoluene

: 1346459-83-3
2-(5-isobutyl-[1,1'-biphenyl]-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

: 1346459-85-5
2-(5-isobutylbiphenyl-2-yl)-3-phenyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / 1,4-dioxane; water / 80 °C

2: toluene / 28 h / 20 °C / Reflux

3: water; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone / tert-Amyl alcohol / 12 h / 100 °C / Inert atmosphere

With ammonia; water; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone; In 1,4-dioxane; tert-Amyl alcohol; water; toluene;
DOI:10.1246/cl.2011.1004