1346459-76-4

Upstream product

• 651-83-2 4-trifluoromethyl-2,3,5,6-tetrafluoroaniline 
• 71381-91-4 (+/-)-2-(4-isobutylphenyl)propanoyl chloride 

Downstream Products

• 1346459-83-3 2-(5-isobutyl-[1,1'-biphenyl]-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide 
• 1346459-85-5 2-(5-isobutylbiphenyl-2-yl)-3-phenyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide 
• 1446442-49-4 2-(2-iodo-4-isobutylphenyl)-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]propanamide 
• 1446442-50-7 2-(2,6-diiodo-4-isobutylphenyl)-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]propanamide 

Relevant academic research and scientific papers

Ligand-Enabled Cross-Coupling of C(sp3)-H Bonds with Arylsilanes

Pd(II)-catalyzed cross-coupling of C(sp3)-H bonds with organosilicon coupling partners has been achieved for the first time. The use of a newly developed quinoline-based ligand is essential for the cross-coupling reactions to proceed.

Pd(II)-catalyzed C-H iodination using molecular I2 as the sole oxidant

Pd-catalyzed ortho-C-H iodination directed by a weakly coordinating amide auxiliary using I2 as the sole oxidant was developed. This reaction is compatible with a wide range of heterocycles including pyridines, imidazoles, oxazoles, thiazoles, isoxazoles, and pyrazoles.

Pd(II)-catalyzed cross-coupling of C(sp2)h bonds and alkyl, aryl, and vinylboron reagents via Pd(II)/Pd(0) catalysis

Pd(II)-catalyzed cross-coupling of ortho-CH bonds in benzoic acid and phenylacetic acid amides with alkyl, aryl, and vinylboron reagents have been achieved via Pd(II)/Pd(0) catalysis, demonstrating the unprecedented versatility of CH activation reactions.