2-{2-[2-(3-bromo-5-nitro-phenoxy)-ethoxy]-ethoxy}-ethanol

Base Information

• Chemical Name: 2-{2-[2-(3-bromo-5-nitro-phenoxy)-ethoxy]-ethoxy}-ethanol
• CAS No.: 318262-05-4
• Molecular Formula: C₁₂H₁₆BrNO₆
• Molecular Weight: 350.166
• Mol file: 318262-05-4.mol

Synonyms:2-{2-[2-(3-bromo-5-nitro-phenoxy)-ethoxy]-ethoxy}-ethanol

Chemical Property of 2-{2-[2-(3-bromo-5-nitro-phenoxy)-ethoxy]-ethoxy}-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{2-[2-(3-bromo-5-nitro-phenoxy)-ethoxy]-ethoxy}-ethanol

There total 1 articles about 2-{2-[2-(3-bromo-5-nitro-phenoxy)-ethoxy]-ethoxy}-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-5-nitro-phenol (116632-23-6) + 2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → 2-{2-[2-(3-bromo-5-nitro-phenoxy)-ethoxy]-ethoxy}-ethanol (318262-05-4)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/ja002129e

Reference yield:

2-{2-[2-(3-bromo-5-nitro-phenoxy)-ethoxy]-ethoxy}-ethanol (318262-05-4) → C68H83N3O20

Guidance literature:

Multi-step reaction with 9 steps

1.1: graphite; hydrazine hydrate / ethanol / 2 h / Heating

2.1: aq. sodium nitrite; conc. HCl / acetonitrile / 0.5 h / 0 °C

2.2: aq. K₂CO₃ / acetonitrile / 0.17 h / 20 °C

3.1: 72 percent / CuI; PPh₃; NEt₃ / Pd₂(dba)3 / 18 h / 80 °C

4.1: 95 percent / pyridine / 7 h / 20 °C

5.1: 94 percent / CH₃I / 12 h / 110 °C

6.1: 95 percent / CuI; PPh₃; NEt₃ / Pd₂(dba)3 / 70 °C

7.1: 80 percent / CH₃I / 12 h / 110 °C

8.1: 88 percent / CuI; PPh₃; NEt₃ / Pd₂(dba)3 / acetonitrile / 70 °C

9.1: TBAF; H₂O / tetrahydrofuran / 0.01 h / 20 °C

With pyridine; hydrogenchloride; copper(l) iodide; tetrabutyl ammonium fluoride; water; pyrographite; hydrazine hydrate; triethylamine; triphenylphosphine; sodium nitrite; methyl iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; ethanol; acetonitrile;

DOI:10.1021/ja002129e

Reference yield:

2-{2-[2-(3-bromo-5-nitro-phenoxy)-ethoxy]-ethoxy}-ethanol (318262-05-4) → C71H91N3O20Si

Guidance literature:

Multi-step reaction with 8 steps

1.1: graphite; hydrazine hydrate / ethanol / 2 h / Heating

2.1: aq. sodium nitrite; conc. HCl / acetonitrile / 0.5 h / 0 °C

2.2: aq. K₂CO₃ / acetonitrile / 0.17 h / 20 °C

3.1: 72 percent / CuI; PPh₃; NEt₃ / Pd₂(dba)3 / 18 h / 80 °C

4.1: 95 percent / pyridine / 7 h / 20 °C

5.1: 94 percent / CH₃I / 12 h / 110 °C

6.1: 95 percent / CuI; PPh₃; NEt₃ / Pd₂(dba)3 / 70 °C

7.1: 80 percent / CH₃I / 12 h / 110 °C

8.1: 88 percent / CuI; PPh₃; NEt₃ / Pd₂(dba)3 / acetonitrile / 70 °C

With pyridine; hydrogenchloride; copper(l) iodide; pyrographite; hydrazine hydrate; triethylamine; triphenylphosphine; sodium nitrite; methyl iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In ethanol; acetonitrile;

DOI:10.1021/ja002129e

upstream raw materials:

3-bromo-5-nitro-phenol

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Downstream raw materials:

2-{2-[2-(3-amino-5-bromo-phenoxy)-ethoxy]-ethoxy}-ethanol

acetic acid 2-{2-[2-(3-iodo-5-trimethylsilanylethynyl-phenoxy)-ethoxy]-ethoxy}-ethyl ester

acetic acid 2-(2-{2-[3-(3-{2-[2-(2-acetoxy-ethoxy)-ethoxy]-ethoxy}-5-iodo-phenylethynyl)-5-trimethylsilanylethynyl-phenoxy]-ethoxy}-ethoxy)-ethyl ester