acetic acid 2-{2-[2-(3-iodo-5-trimethylsilanylethynyl-phenoxy)-ethoxy]-ethoxy}-ethyl ester

Base Information

Chemical Name:acetic acid 2-{2-[2-(3-iodo-5-trimethylsilanylethynyl-phenoxy)-ethoxy]-ethoxy}-ethyl ester
CAS No.:318262-12-3
Molecular Formula:C₁₉H₂₇IO₅Si
Molecular Weight:490.41
Hs Code.:

Synonyms:acetic acid 2-{2-[2-(3-iodo-5-trimethylsilanylethynyl-phenoxy)-ethoxy]-ethoxy}-ethyl ester

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Chemical Property of acetic acid 2-{2-[2-(3-iodo-5-trimethylsilanylethynyl-phenoxy)-ethoxy]-ethoxy}-ethyl ester

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Technology Process of acetic acid 2-{2-[2-(3-iodo-5-trimethylsilanylethynyl-phenoxy)-ethoxy]-ethoxy}-ethyl ester

There total 7 articles about acetic acid 2-{2-[2-(3-iodo-5-trimethylsilanylethynyl-phenoxy)-ethoxy]-ethoxy}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: C₂₃H₃₇N₃O₅Si

: 318262-12-3
acetic acid 2-{2-[2-(3-iodo-5-trimethylsilanylethynyl-phenoxy)-ethoxy]-ethoxy}-ethyl ester

Guidance literature:: With methyl iodide; at 110 ℃; for 12h;
DOI:10.1021/ja002129e

Reference yield:

: 318262-07-6
2-{2-[2-(3-amino-5-bromo-phenoxy)-ethoxy]-ethoxy}-ethanol

: 318262-12-3
acetic acid 2-{2-[2-(3-iodo-5-trimethylsilanylethynyl-phenoxy)-ethoxy]-ethoxy}-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. sodium nitrite; conc. HCl / acetonitrile / 0.5 h / 0 °C

1.2: aq. K₂CO₃ / acetonitrile / 0.17 h / 20 °C

2.1: 72 percent / CuI; PPh₃; NEt₃ / Pd₂(dba)3 / 18 h / 80 °C

3.1: 95 percent / pyridine / 7 h / 20 °C

4.1: 94 percent / CH₃I / 12 h / 110 °C

With pyridine; hydrogenchloride; copper(l) iodide; triethylamine; triphenylphosphine; sodium nitrite; methyl iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In acetonitrile;
DOI:10.1021/ja002129e

Reference yield:

: 318262-05-4
2-{2-[2-(3-bromo-5-nitro-phenoxy)-ethoxy]-ethoxy}-ethanol

: 318262-12-3
acetic acid 2-{2-[2-(3-iodo-5-trimethylsilanylethynyl-phenoxy)-ethoxy]-ethoxy}-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: graphite; hydrazine hydrate / ethanol / 2 h / Heating

2.1: aq. sodium nitrite; conc. HCl / acetonitrile / 0.5 h / 0 °C

2.2: aq. K₂CO₃ / acetonitrile / 0.17 h / 20 °C

3.1: 72 percent / CuI; PPh₃; NEt₃ / Pd₂(dba)3 / 18 h / 80 °C

4.1: 95 percent / pyridine / 7 h / 20 °C

5.1: 94 percent / CH₃I / 12 h / 110 °C

With pyridine; hydrogenchloride; copper(l) iodide; pyrographite; hydrazine hydrate; triethylamine; triphenylphosphine; sodium nitrite; methyl iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In ethanol; acetonitrile;
DOI:10.1021/ja002129e