2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl 4-chloro-3-nitrobenzoate

Base Information

• Chemical Name: 2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl 4-chloro-3-nitrobenzoate
• CAS No.: 1448620-78-7
• Molecular Formula: C₁₆H₁₈ClNO₇
• Molecular Weight: 371.774
• Mol file: 1448620-78-7.mol

Synonyms:2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl 4-chloro-3-nitrobenzoate

Chemical Property of 2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl 4-chloro-3-nitrobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl 4-chloro-3-nitrobenzoate

There total 2 articles about 2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl 4-chloro-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-chloro-3-nitrobenzoate (96-99-1) + O-propargyl triethylene glycol (208827-90-1) → 2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl 4-chloro-3-nitrobenzoate (1448620-78-7)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/jo401278x

Reference yield:

2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → 2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl 4-chloro-3-nitrobenzoate (1448620-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 2: |Mitsunobu Displacement;

DOI:10.1021/jo401278x

Reference yield: 45.0%

GLUTATHIONE (70-18-8) + 2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl 4-chloro-3-nitrobenzoate (1448620-78-7) → C27H36N4O12S

Guidance literature:

With glutathione S-transferase; In methanol; aq. phosphate buffer; at 25 ℃; pH=7; Reagent/catalyst; Inert atmosphere; Enzymatic reaction;

DOI:10.1021/jo401278x

upstream raw materials:

4-chloro-3-nitrobenzoate

O-propargyl triethylene glycol

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Downstream raw materials:

C₂₆H₃₄N₄O₁₃S