(S)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-3-phenyl-propionic acid methyl ester

Base Information

• Chemical Name: (S)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-3-phenyl-propionic acid methyl ester
• CAS No.: 108353-31-7
• Molecular Formula: C₂₂H₂₄N₂O₄S
• Molecular Weight: 412.51
• Mol file: 108353-31-7.mol

Synonyms:(S)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-3-phenyl-propionic acid methyl ester

Chemical Property of (S)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-3-phenyl-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-3-phenyl-propionic acid methyl ester

There total 2 articles about (S)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) + 5-(dimethylamino)naphth-1-ylsulfonyl chloride (605-65-2) → (S)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-3-phenyl-propionic acid methyl ester (108353-31-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1039/c5cc00261c

Reference yield:

→ (S)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-3-phenyl-propionic acid methyl ester (108353-31-7)

Guidance literature:

aus dem Sulfonylchlorid und 1. Phe, 2. CH3OH/HCl;

DOI:10.1042/bj1100603

Reference yield:

(S)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-3-phenyl-propionic acid methyl ester (108353-31-7) → dansyl-L-phenylalanine (1104-36-5)

Guidance literature:

With lithium hydroxide; In methanol; at 20 ℃;

DOI:10.1039/c5cc00261c

upstream raw materials:

methyl (2S)-2-amino-3-phenylpropanoate

5-(dimethylamino)naphth-1-ylsulfonyl chloride

Downstream raw materials:

dansyl-L-phenylalanine