tert-butyl 4-(4-formyl-3-hydroxyphenyl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(4-formyl-3-hydroxyphenyl)piperazine-1-carboxylate
• CAS No.: 1446332-69-9
• Molecular Formula: C₁₆H₂₂N₂O₄
• Molecular Weight: 306.362
• Mol file: 1446332-69-9.mol

Synonyms:tert-butyl 4-(4-formyl-3-hydroxyphenyl)piperazine-1-carboxylate

Chemical Property of tert-butyl 4-(4-formyl-3-hydroxyphenyl)piperazine-1-carboxylate

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(4-formyl-3-hydroxyphenyl)piperazine-1-carboxylate 98% ^*data from reagent suppliers

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Technology Process of tert-butyl 4-(4-formyl-3-hydroxyphenyl)piperazine-1-carboxylate

There total 2 articles about tert-butyl 4-(4-formyl-3-hydroxyphenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-fluoro-2-hydroxybenzaldehyde (348-28-7) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(4-formyl-3-hydroxyphenyl)piperazine-1-carboxylate (1446332-69-9)

Guidance literature:

In dimethyl sulfoxide; at 100 ℃; for 27h;

Reference yield: 34.0%

1,1-dimethylethyl 4-(3-hydroxyphenyl)-1-piperazinecarboxylate (198627-86-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → tert-butyl 4-(4-formyl-3-hydroxyphenyl)piperazine-1-carboxylate (1446332-69-9)

Guidance literature:

With trichlorophosphate; at 20 ℃;

DOI:10.1039/C8SC03781G

Reference yield: 69.0%

tert-butyl 4-(4-formyl-3-hydroxyphenyl)piperazine-1-carboxylate (1446332-69-9) + 3-dicyanomethylidene-1,5,5-trimethylcyclohexene (23051-44-7) → C28H34N4O3

Guidance literature:

With piperidine; In ethanol; for 3h; Reflux;

DOI:10.1021/acs.analchem.1c04596

upstream raw materials:

4-fluoro-2-hydroxybenzaldehyde

1-t-Butoxycarbonylpiperazine

1,1-dimethylethyl 4-(3-hydroxyphenyl)-1-piperazinecarboxylate

N,N-dimethyl-formamide

Downstream raw materials:

tert-butyl 4-(2-oxo-3-(5-phenyl-1,2,4-oxadiazol-3-yl)-2H-chromen-7-yl)piperazine-1-carboxylate

3-(5-phenyl-1,2,4-oxadiazol-3-yl)-7-(piperazin-1-yl)-2H-chromen-2-one

tert-butyl 4-(2-oxo-3-(1-phenyl-1H-pyrazol-3-yl)-2H-chromen-7-yl)piperazine-1-carboxylate

3-(1-phenyl-1H-pyrazol-3-yl)-7-(piperazin-1-yl)-2H-chromen-2-one

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