3-Pentynoicacid,2-[[(1,1-dimethylethoxy)carbonyl]amino]-,(R)-(9CI)

Base Information

Chemical Name:3-Pentynoicacid,2-[[(1,1-dimethylethoxy)carbonyl]amino]-,(R)-(9CI)
CAS No.:182495-27-8
Molecular Formula:C₁₀H₁₅NO₄
Molecular Weight:213.233
Hs Code.:
Mol file:182495-27-8.mol

Synonyms:3-Pentynoicacid,2-[[(1,1-dimethylethoxy)carbonyl]amino]-,(R)-(9CI)

Suppliers and Price of 3-Pentynoicacid,2-[[(1,1-dimethylethoxy)carbonyl]amino]-,(R)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Pentynoicacid,2-[[(1,1-dimethylethoxy)carbonyl]amino]-,(R)-(9CI)

Chemical Property:

PSA：75.63000
LogP:1.37850

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Pentynoicacid,2-[[(1,1-dimethylethoxy)carbonyl]amino]-,(R)-(9CI)

There total 4 articles about 3-Pentynoicacid,2-[[(1,1-dimethylethoxy)carbonyl]amino]-,(R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 182495-17-6
((R)-1-Hydroxymethyl-but-2-ynyl)-carbamic acid tert-butyl ester

: 182495-32-5
(1-Oxo-but-2-ynyl)-carbamic acid tert-butyl ester

: 182495-27-8
(R)-2-tert-Butoxycarbonylamino-pent-3-ynoic acid

Guidance literature:: With jones reagent; In acetone; at 0 ℃; for 2h;
DOI:10.1016/0040-4020(96)00630-8

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 182495-27-8
(R)-2-tert-Butoxycarbonylamino-pent-3-ynoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: aq. Na₂CO₃, NaHCO₃ / dioxane / 1.) 0 deg C, overnight, 2.) 25 deg C, 8 h

2: 26 percent / Jones reagent / acetone / 2 h / 0 °C

With jones reagent; sodium hydrogencarbonate; sodium carbonate; In 1,4-dioxane; acetone;
DOI:10.1016/0040-4020(96)00630-8

Reference yield:

: 173065-20-8
1,1-dimethylethyl (4R)-2,2-dimethyl-4--3-oxazolidine carboxylate

: 182495-27-8
(R)-2-tert-Butoxycarbonylamino-pent-3-ynoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: TFA / methanol / 2 h / Ambient temperature

2: aq. Na₂CO₃, NaHCO₃ / dioxane / 1.) 0 deg C, overnight, 2.) 25 deg C, 8 h

3: 26 percent / Jones reagent / acetone / 2 h / 0 °C

With jones reagent; sodium hydrogencarbonate; sodium carbonate; trifluoroacetic acid; In 1,4-dioxane; methanol; acetone;
DOI:10.1016/0040-4020(96)00630-8