D-Norvaline, N-[(1,1-diMethylethoxy)carbonyl]-, Methyl ester

Base Information

• Chemical Name: D-Norvaline, N-[(1,1-diMethylethoxy)carbonyl]-, Methyl ester
• CAS No.: 116611-58-6
• Molecular Formula: C₁₁H₂₁NO₄
• Molecular Weight: 231.292
• Mol file: 116611-58-6.mol

Synonyms:D-Norvaline, N-[(1,1-diMethylethoxy)carbonyl]-, Methyl ester

Chemical Property of D-Norvaline, N-[(1,1-diMethylethoxy)carbonyl]-, Methyl ester

Chemical Property:

• PSA: 64.63000
• LogP: 2.24370

Purity/Quality:

≥95% ^*data from raw suppliers

D-Norvaline,N-[(1,1-dimethylethoxy)carbonyl]-,methylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of D-Norvaline, N-[(1,1-diMethylethoxy)carbonyl]-, Methyl ester

There total 15 articles about D-Norvaline, N-[(1,1-diMethylethoxy)carbonyl]-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + N-tert-butoxycarbonyl-D-norvaline (57521-85-4) → (R)-2-tert-butoxycarbonylaminopentanoic acid methyl ester (116611-58-6)

Guidance literature:

With potassium hydroxide; In diethyl ether; at 0 ℃; for 1h;

DOI:10.1016/j.tet.2006.01.005

Reference yield: 98.0%

D,L-N-Boc-nor-valine methyl ester (142729-70-2) → N-tert-butoxycarbonyl-L-norvaline (53308-95-5) + (R)-2-tert-butoxycarbonylaminopentanoic acid methyl ester (116611-58-6)

Guidance literature:

With Bacillus licheniformis; In water; at 30 ℃; for 15h; pH=7.5;

DOI:10.1016/j.tetasy.2006.07.012

Reference yield: 91.0%

di-tert-butyl dicarbonate (24424-99-5) + (R)-methyl 2-aminopentanoate hydrochloride (619330-91-5) → (R)-2-tert-butoxycarbonylaminopentanoic acid methyl ester (116611-58-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.7b00621

upstream raw materials:

methyllithium

tert-Butyloxycarbonyl-L-α-amino-γ-bromobutyric acid methyl ester

methanol

N-tert-butoxycarbonyl-D-norvaline

Downstream raw materials:

(2R)-2-(1,1-dimethylethoxycarbonylamino)pentanal

tert-butyl (1R,2Z,6R,7R,9R)-(10-benzyloxy-6-hydroxy-7,9-dimethyl-8-oxo-1-propyl-dec-2-enyl)-carbamate

tert-butyl (1R,2E,6R,7R,9R)-(10-benzyloxy-6-hydroxy-7,9-dimethyl-8-oxo-1-propyl-dec-2-enyl)-carbamate

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