{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-phenyl}acetaldehyde

Base Information

Chemical Name:{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-phenyl}acetaldehyde
CAS No.:1151805-31-0
Molecular Formula:C₂₀H₁₄F₂N₂O₃
Molecular Weight:368.34
Hs Code.:

Synonyms:{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-phenyl}acetaldehyde

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Chemical Property of {4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-phenyl}acetaldehyde

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Technology Process of {4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-phenyl}acetaldehyde

There total 4 articles about {4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-phenyl}acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 602312-20-9
6-amino-5-(2,4-difluorobenzoyl)-1-[4-(2-hydroxyethyl)phenyl]-pyridin-2(1H)-one

: 1151805-31-0
{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-phenyl}acetaldehyde

Guidance literature:: 6-amino-5-(2,4-difluorobenzoyl)-1-[4-(2-hydroxyethyl)phenyl]-pyridin-2(1H)-one; With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 3h;

With sodium hydrogencarbonate; sodium thiosulfate; In dichloromethane; water; for 0.5h;

Reference yield:

: 1151805-27-4
2-(4-{[3-(2,4-difluorophenyl)-3-oxopropanimidoyl]-amino}phenyl)ethyl acetate

: 1151805-31-0
{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-phenyl}acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: 20 - 80 °C / Inert atmosphere

2.1: hydrogenchloride / water / 2 h / Reflux

2.2: 0.5 h

3.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

With hydrogenchloride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 764645-61-6
4-chlorophenyl 3-(2,4-difluorophenyl)-3-oxo-propanimidothioate

: 1151805-31-0
{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-phenyl}acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 2.5 h / 80 °C

1.2: 0.5 h

2.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: 20 - 80 °C / Inert atmosphere

3.1: hydrogenchloride / water / 2 h / Reflux

3.2: 0.5 h

4.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

With hydrogenchloride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water; acetic acid;