2'-O-(di-tert-butoxyphosphoryl)-5'-O-dimethoxytrityl-6N-benzoyladenosine

Base Information

Chemical Name:2'-O-(di-tert-butoxyphosphoryl)-5'-O-dimethoxytrityl-6N-benzoyladenosine
CAS No.:289697-88-7
Molecular Formula:C₄₆H₅₂N₅O₁₀P
Molecular Weight:865.92
Hs Code.:

Synonyms:2'-O-(di-tert-butoxyphosphoryl)-5'-O-dimethoxytrityl-6N-benzoyladenosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-O-(di-tert-butoxyphosphoryl)-5'-O-dimethoxytrityl-6N-benzoyladenosine

Chemical Property:

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Technology Process of 2'-O-(di-tert-butoxyphosphoryl)-5'-O-dimethoxytrityl-6N-benzoyladenosine

There total 7 articles about 2'-O-(di-tert-butoxyphosphoryl)-5'-O-dimethoxytrityl-6N-benzoyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117924-33-1
di-tert-butyl N,N-diethylphosphoramidite

: 289697-88-7
2'-O-(di-tert-butoxyphosphoryl)-5'-O-dimethoxytrityl-6N-benzoyladenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) tetrazole, 2.) mCPBA / 1.) CH₂Cl₂, 2 h, 2.) 0 deg C, 1 h

2: HF*pyridine, pyridine / tetrahydrofuran / 10.5 h / Ambient temperature

3: pyridine

With pyridine; 1H-tetrazole; pyridine hydrogenfluoride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran;
DOI:10.1021/jo00063a055

Reference yield:

: 148692-01-7
N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl adenosine

: 289697-88-7
2'-O-(di-tert-butoxyphosphoryl)-5'-O-dimethoxytrityl-6N-benzoyladenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) tetrazole, 2.) mCPBA / 1.) CH₂Cl₂, 3 h, 2.) 0 deg C, 1 h

2: tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 2 h

3: pyridine

With pyridine; 1H-tetrazole; tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran;
DOI:10.1021/jo00063a055

Reference yield:

: 148692-02-8
2'-O-(di-tert-butoxyphosphoryl)-3',5'-O-(di-tert-butylsilanediyl)-6-N-benzoyladenosine

: 289697-88-7
2'-O-(di-tert-butoxyphosphoryl)-5'-O-dimethoxytrityl-6N-benzoyladenosine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 2 h

2: pyridine

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/jo00063a055