tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfanyl]acetate

Base Information

• Chemical Name: tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfanyl]acetate
• CAS No.: 1048364-43-7
• Molecular Formula: C₁₄H₁₄F₆O₂S
• Molecular Weight: 360.32
• Mol file: 1048364-43-7.mol

Synonyms:tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfanyl]acetate

Chemical Property of tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfanyl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfanyl]acetate

There total 3 articles about tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfanyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 3,5-bis(trifluoromethyl)thiophenol (130783-02-7) → tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfanyl]acetate (1048364-43-7)

Guidance literature:

3,5-bis(trifluoromethyl)thiophenol; With triethylamine; In acetonitrile; at 20 ℃; for 0.25h; Inert atmosphere;

bromoacetic acid tert-butyl ester; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.200800041

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + C10H6F6O2S (1427308-57-3) + allyl alcohol (107-18-6) → tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfanyl]acetate (1048364-43-7) + allyl 2-((3,5-bis(trifluoromethyl)phenyl)thio)acetate (1427308-55-1)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 - 23 ℃; for 18h;

DOI:10.1080/00397911.2011.640970

Reference yield:

C12H10F6O2S (1427308-53-9) → tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfanyl]acetate (1048364-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water; tetrahydrofuran

2: pyridine; dmap / dichloromethane / 18 h / 0 - 23 °C

With pyridine; dmap; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1080/00397911.2011.640970

upstream raw materials:

bromoacetic acid tert-butyl ester

3,5-bis(trifluoromethyl)thiophenol

di-tert-butyl dicarbonate

C₁₀H₆F₆O₂S

Downstream raw materials:

tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]acetate