tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]acetate

Base Information

• Chemical Name: tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]acetate
• CAS No.: 1048364-45-9
• Molecular Formula: C₁₄H₁₄F₆O₄S
• Molecular Weight: 392.319
• Mol file: 1048364-45-9.mol

Synonyms:tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]acetate

Chemical Property of tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]acetate

There total 1 articles about tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfanyl]acetate (1048364-43-7) → tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]acetate (1048364-45-9)

Guidance literature:

With oxone; In methanol; water; at 20 ℃; for 24h;

DOI:10.1002/ejoc.200800041

Reference yield: 95.0%

tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]acetate (1048364-45-9) + benzaldehyde (100-52-7) → tert-butyl cinnamate (14990-09-1)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 18h; diastereospecific reaction; Inert atmosphere;

DOI:10.1002/ejoc.200800041

Reference yield: 65.0%

tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]acetate (1048364-45-9) → C14H13F7O4S (1075204-18-0)

Guidance literature:

tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]acetate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

With Selectfluor; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/adsc.200800194

upstream raw materials:

tert-butyl 2-[3,5-bis(trifluoromethyl)phenylsulfanyl]acetate

Downstream raw materials:

tert-butyl (E)-2-{[3,5-bis(trifluoromethyl)phenyl]sulfonyl}-4-phenylbut-3-enoate

tert-butyl (E)-3-(4-chlorophenyl)prop-2-enoate

tert-butyl (2E)-3-(2-chlorophenyl)acrylate

tert-butyl cinnamate