Technology Process of 3-(5-bromo-2-iodophenyl)-2,2-dimethylpropanenitrile
There total 3 articles about 3-(5-bromo-2-iodophenyl)-2,2-dimethylpropanenitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Isobutyronitrile;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
5-bromo-1-(bromomethyl)-2-iodobenzene;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
Further stages.;
DOI:10.1021/jo0262006
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: BH3*SMe2 / tetrahydrofuran / 0 - 20 °C
2.1: CBr4; PPH3 / CH2Cl2 / 0 °C
3.1: n-BuLi; i-Pr2NH / hexane; tetrahydrofuran / 1 h / -78 °C
3.2: 48 percent / tetrahydrofuran; hexane / -78 - 20 °C
With
n-butyllithium; carbon tetrabromide; dimethylsulfide borane complex; diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo0262006
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: CBr4; PPH3 / CH2Cl2 / 0 °C
2.1: n-BuLi; i-Pr2NH / hexane; tetrahydrofuran / 1 h / -78 °C
2.2: 48 percent / tetrahydrofuran; hexane / -78 - 20 °C
With
n-butyllithium; carbon tetrabromide; diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo0262006
