trans-4-{4'-ethoxy-2,2',3,3'-tetrafluoro-[1,1'-biphenyl]-4-yl}cyclohexyl-trans-4-[2,3-difluoro-4-(hexyloxy)phenyl]cyclohexylcarboxylate

Base Information

Chemical Name:trans-4-{4'-ethoxy-2,2',3,3'-tetrafluoro-[1,1'-biphenyl]-4-yl}cyclohexyl-trans-4-[2,3-difluoro-4-(hexyloxy)phenyl]cyclohexylcarboxylate
CAS No.:1338447-74-7
Molecular Formula:C₃₉H₄₄F₆O₄
Molecular Weight:690.766
Hs Code.:

Synonyms:trans-4-{4'-ethoxy-2,2',3,3'-tetrafluoro-[1,1'-biphenyl]-4-yl}cyclohexyl-trans-4-[2,3-difluoro-4-(hexyloxy)phenyl]cyclohexylcarboxylate

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Chemical Property of trans-4-{4'-ethoxy-2,2',3,3'-tetrafluoro-[1,1'-biphenyl]-4-yl}cyclohexyl-trans-4-[2,3-difluoro-4-(hexyloxy)phenyl]cyclohexylcarboxylate

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Technology Process of trans-4-{4'-ethoxy-2,2',3,3'-tetrafluoro-[1,1'-biphenyl]-4-yl}cyclohexyl-trans-4-[2,3-difluoro-4-(hexyloxy)phenyl]cyclohexylcarboxylate

There total 15 articles about trans-4-{4'-ethoxy-2,2',3,3'-tetrafluoro-[1,1'-biphenyl]-4-yl}cyclohexyl-trans-4-[2,3-difluoro-4-(hexyloxy)phenyl]cyclohexylcarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.6%

: 1338448-94-4
trans-4-(4-hexyloxy-2,3-difluorophenyl)-cyclohexylcarboxylic acid

: trans-4-{4'-ethoxy-2,2',3,3'-tetrafluoro-[1,1'-biphenyl]-4-yl}cyclohexanol

: 1338447-74-7
trans-4-{4'-ethoxy-2,2',3,3'-tetrafluoro-[1,1'-biphenyl]-4-yl}cyclohexyl-trans-4-[2,3-difluoro-4-(hexyloxy)phenyl]cyclohexylcarboxylate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In toluene; at 25 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1122-58-3
dmap

: 1,3-Dicyclohexylcarbodiimide (DCC)

: 1338448-94-4
trans-4-(4-hexyloxy-2,3-difluorophenyl)-cyclohexylcarboxylic acid

: trans-4-{4'-ethoxy-2,2',3,3'-tetrafluoro-[1,1'-biphenyl]-4-yl}cyclohexanol

: 1338447-74-7
trans-4-{4'-ethoxy-2,2',3,3'-tetrafluoro-[1,1'-biphenyl]-4-yl}cyclohexyl-trans-4-[2,3-difluoro-4-(hexyloxy)phenyl]cyclohexylcarboxylate

Guidance literature:: In water; toluene;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1338447-74-7
trans-4-{4'-ethoxy-2,2',3,3'-tetrafluoro-[1,1'-biphenyl]-4-yl}cyclohexyl-trans-4-[2,3-difluoro-4-(hexyloxy)phenyl]cyclohexylcarboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sec.-butyllithium / tetrahydrofuran; cyclohexane; hexane / 2 h / -74 - -70 °C / Inert atmosphere

1.2: 8 h / -75 - -70 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 2 h / Reflux

2.2: 20 °C

3.1: formic acid / toluene / 2 h / Reflux

4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -30 - -10 °C / Inert atmosphere

4.2: 2 h / Inert atmosphere; Reflux

5.1: formic acid / toluene / 2 h / Reflux

6.1: Oxone / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

7.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -30 - -20 °C / Reflux

7.2: 0.5 h / -30 - -10 °C

8.1: formic acid / toluene / 2 h / Reflux

9.1: Oxone / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

10.1: dicyclohexyl-carbodiimide; dmap / toluene / 20 h / 25 °C / Inert atmosphere

With dmap; Oxone; formic acid; potassium tert-butylate; sec.-butyllithium; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; cyclohexane; N,N-dimethyl-formamide; toluene;