2-(4-biphenylyl)-1-({(3RS)-1-[(dimethylamino)carbonyl]-3-pyrrolidinyl}methyl)-N-methyl-1H-benzimidazole-6-carboxamide

Base Information

Chemical Name:2-(4-biphenylyl)-1-({(3RS)-1-[(dimethylamino)carbonyl]-3-pyrrolidinyl}methyl)-N-methyl-1H-benzimidazole-6-carboxamide
CAS No.:1301188-36-2
Molecular Formula:C₂₉H₃₁N₅O₂
Molecular Weight:481.597
Hs Code.:

Synonyms:2-(4-biphenylyl)-1-({(3RS)-1-[(dimethylamino)carbonyl]-3-pyrrolidinyl}methyl)-N-methyl-1H-benzimidazole-6-carboxamide

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Chemical Property of 2-(4-biphenylyl)-1-({(3RS)-1-[(dimethylamino)carbonyl]-3-pyrrolidinyl}methyl)-N-methyl-1H-benzimidazole-6-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(4-biphenylyl)-1-({(3RS)-1-[(dimethylamino)carbonyl]-3-pyrrolidinyl}methyl)-N-methyl-1H-benzimidazole-6-carboxamide

There total 9 articles about 2-(4-biphenylyl)-1-({(3RS)-1-[(dimethylamino)carbonyl]-3-pyrrolidinyl}methyl)-N-methyl-1H-benzimidazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1301189-92-3
2-(4-biphenylyl)-N-methyl-1-[(3RS)-3-pyrrolidinylmethyl]-1H-benzimidazole-6-carboxamide

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 1301188-36-2
2-(4-biphenylyl)-1-({(3RS)-1-[(dimethylamino)carbonyl]-3-pyrrolidinyl}methyl)-N-methyl-1H-benzimidazole-6-carboxamide

Guidance literature:: 2-(4-biphenylyl)-N-methyl-1-[(3RS)-3-pyrrolidinylmethyl]-1H-benzimidazole-6-carboxamide; N,N-Dimethylcarbamoyl chloride; With triethylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 72h;

In 1-methyl-pyrrolidin-2-one;

Reference yield:

: 93138-61-5
C-(1-benzyl-pyrrolidin-3-yl)-methylamine

: 1301188-36-2
2-(4-biphenylyl)-1-({(3RS)-1-[(dimethylamino)carbonyl]-3-pyrrolidinyl}methyl)-N-methyl-1H-benzimidazole-6-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: dichloromethane / 12 h / 0 - 20 °C

2.1: hydrogen / palladium(II) hydroxide; palladium 10% on activated carbon / acetic acid; methanol / 48 h / 20 °C

3.1: triethylamine / methanol / 24 h / 0 - 20 °C

4.1: sodium hydroxide; water / methanol / 3 h / 20 °C

5.1: dimethyl sulfoxide / 17 h / 98 °C / Inert atmosphere

6.1: sodium dithionite / ethanol; dimethyl sulfoxide / 23 h / 80 °C

7.1: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 0.75 h / 20 °C

7.2: 22 h / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

9.1: triethylamine / 1-methyl-pyrrolidin-2-one / 72 h / 20 °C

9.2: tris-amine resin

With dmap; sodium dithionite; water; hydrogen; triethylamine; trifluoroacetic acid; sodium hydroxide; diisopropyl-carbodiimide; palladium 10% on activated carbon; palladium(II) hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; acetic acid; dimethyl sulfoxide;

Reference yield:

: 849632-74-2
2,2,2-trifluoro-N-{[(3RS)-1-(phenylmethyl)-3-pyrrolidinyl]methyl}acetamide

: 1301188-36-2
2-(4-biphenylyl)-1-({(3RS)-1-[(dimethylamino)carbonyl]-3-pyrrolidinyl}methyl)-N-methyl-1H-benzimidazole-6-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium(II) hydroxide; palladium 10% on activated carbon / acetic acid; methanol / 48 h / 20 °C

2.1: triethylamine / methanol / 24 h / 0 - 20 °C

3.1: sodium hydroxide; water / methanol / 3 h / 20 °C

4.1: dimethyl sulfoxide / 17 h / 98 °C / Inert atmosphere

5.1: sodium dithionite / ethanol; dimethyl sulfoxide / 23 h / 80 °C

6.1: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 0.75 h / 20 °C

6.2: 22 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

8.1: triethylamine / 1-methyl-pyrrolidin-2-one / 72 h / 20 °C

8.2: tris-amine resin

With dmap; sodium dithionite; water; hydrogen; triethylamine; trifluoroacetic acid; sodium hydroxide; diisopropyl-carbodiimide; palladium 10% on activated carbon; palladium(II) hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; acetic acid; dimethyl sulfoxide;