ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis<(chloroacetamido)methyl>-4-hydroxybenzyl>-2-benzofurancarboxylate

Base Information

Chemical Name:ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis<(chloroacetamido)methyl>-4-hydroxybenzyl>-2-benzofurancarboxylate
CAS No.:95250-08-1
Molecular Formula:C₂₄H₂₄Cl₄N₂O₆
Molecular Weight:578.276
Hs Code.:

Synonyms:ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis<(chloroacetamido)methyl>-4-hydroxybenzyl>-2-benzofurancarboxylate

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Chemical Property of ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis<(chloroacetamido)methyl>-4-hydroxybenzyl>-2-benzofurancarboxylate

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Technology Process of ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis<(chloroacetamido)methyl>-4-hydroxybenzyl>-2-benzofurancarboxylate

There total 4 articles about ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis<(chloroacetamido)methyl>-4-hydroxybenzyl>-2-benzofurancarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90246-55-2
6,7-Dichloro-2,3-dihydro-5-(p-hydroxybenzoyl)-benzofuran-2-carboxylic acid

: 95250-08-1
ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis<(chloroacetamido)methyl>-4-hydroxybenzyl>-2-benzofurancarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / conc. H₂SO₄ / 24 h / Ambient temperature

2: 66 percent / trifluoroacetic acid, NaBH₄ / CH₂Cl₂ / Ambient temperature

3: 1.) conc. H₂SO₄, 2.) conc. H₂SO₄ / 1.) acetic acid, RT, overnight, 2.) RT, overnight

With sodium tetrahydroborate; sulfuric acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm50001a009

Reference yield:

: 95249-99-3
ethyl 6,7-dichloro-2,3-dihydro-5-(4-hydroxybenzoyl)-2-benzofurancarboxylate

: 95250-08-1
ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis<(chloroacetamido)methyl>-4-hydroxybenzyl>-2-benzofurancarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / trifluoroacetic acid, NaBH₄ / CH₂Cl₂ / Ambient temperature

2: 1.) conc. H₂SO₄, 2.) conc. H₂SO₄ / 1.) acetic acid, RT, overnight, 2.) RT, overnight

With sodium tetrahydroborate; sulfuric acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm50001a009

Reference yield:

: 90246-58-5
6,7-Dichloro-2,3-dihydro-5-(p-nitrobenzoyl)-benzofuran-2-carboxylic acid

: 95250-08-1
ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis<(chloroacetamido)methyl>-4-hydroxybenzyl>-2-benzofurancarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / acetaldoxime, NaOH / dimethylformamide / Ambient temperature

2: 97 percent / conc. H₂SO₄ / 24 h / Ambient temperature

3: 66 percent / trifluoroacetic acid, NaBH₄ / CH₂Cl₂ / Ambient temperature

4: 1.) conc. H₂SO₄, 2.) conc. H₂SO₄ / 1.) acetic acid, RT, overnight, 2.) RT, overnight

With sodium hydroxide; sodium tetrahydroborate; Acetaldehyde oxime; sulfuric acid; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm50001a009