3-(4-isobutyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

Base Information

Chemical Name:3-(4-isobutyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole
CAS No.:1307812-81-2
Molecular Formula:C₂₄H₂₂F₃NO
Molecular Weight:397.44
Hs Code.:

Synonyms:3-(4-isobutyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

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Chemical Property of 3-(4-isobutyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

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Technology Process of 3-(4-isobutyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

There total 6 articles about 3-(4-isobutyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.5%

: 957206-17-6
4-isobutyl-3-trifluoromethylbenzoic acid methyl ester

: 1307812-05-0
6-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime

: 1307812-81-2
3-(4-isobutyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

Guidance literature:: 4-isobutyl-3-trifluoromethylbenzoic acid methyl ester; 6-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime; With lithium diisopropyl amide; at 0 ℃; for 0.2h;

With thionyl chloride; pyridine; In toluene; at 110 ℃; for 0.0833333h;

Reference yield:

: 3470-50-6
6-Hydroxy-1-tetralone

: 1307812-81-2
3-(4-isobutyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 4 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

4.1: lithium diisopropyl amide / 0.2 h / 0 °C

4.2: 0.08 h / 110 °C

With pyridine; hydroxylamine hydrochloride; sodium acetate; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol;

Reference yield:

: 1735-53-1
4-bromo-3-(trifluoromethyl)benzonitrile

: 1307812-81-2
3-(4-isobutyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 3 h / 20 - 70 °C / Inert atmosphere

1.2: 14 h / 110 °C

2.1: diazomethyl-trimethyl-silane / dichloromethane / 0.5 h / 0 °C

2.2: 20 °C

3.1: lithium diisopropyl amide / 0.2 h / 0 °C

3.2: 0.08 h / 110 °C

With lithium diisopropyl amide; diazomethyl-trimethyl-silane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane;