(2S,3R,4R,5R)-2,4-dimethyl-5-(4-methoxybenzyloxy)-3,4-<1-(4-methoxyphenyl)ethylidenedioxy>heptanal

Base Information

• Chemical Name: (2S,3R,4R,5R)-2,4-dimethyl-5-(4-methoxybenzyloxy)-3,4-<1-(4-methoxyphenyl)ethylidenedioxy>heptanal
• CAS No.: 114825-78-4
• Molecular Formula: C₂₆H₃₄O₆
• Molecular Weight: 442.552
• Mol file: 114825-78-4.mol

Synonyms:(2S,3R,4R,5R)-2,4-dimethyl-5-(4-methoxybenzyloxy)-3,4-<1-(4-methoxyphenyl)ethylidenedioxy>heptanal

Chemical Property of (2S,3R,4R,5R)-2,4-dimethyl-5-(4-methoxybenzyloxy)-3,4-<1-(4-methoxyphenyl)ethylidenedioxy>heptanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R,4R,5R)-2,4-dimethyl-5-(4-methoxybenzyloxy)-3,4-<1-(4-methoxyphenyl)ethylidenedioxy>heptanal

There total 10 articles about (2S,3R,4R,5R)-2,4-dimethyl-5-(4-methoxybenzyloxy)-3,4-<1-(4-methoxyphenyl)ethylidenedioxy>heptanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2S,3R,4R,5R)-2,4-dimethyl-5-(4-methoxybenzyloxy)-3,4-<1-(4-methoxyphenyl)ethylidenedioxy>heptan-1-ol (114825-77-3) → (2S,3R,4R,5R)-2,4-dimethyl-5-(4-methoxybenzyloxy)-3,4-<1-(4-methoxyphenyl)ethylidenedioxy>heptanal (114825-78-4)

Guidance literature:

With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide; at -60 - -50 ℃; for 0.5h;

DOI:10.1248/cpb.37.1160

Reference yield:

(S)-2-[(4R,5R)-5-[(S)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-propan-1-ol (114825-77-3) → (R)-2-[(4R,5R)-5-[(S)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-propionaldehyde (114825-78-4)

Guidance literature:

With oxalyl dichloride; triethylamine; In dimethyl sulfoxide; Yield given;

DOI:10.1016/S0040-4039(00)96566-3

Reference yield:

1,1-dimethoxy-1-(4-methoxyphenyl)ethane (27150-99-8) → (R)-2-[(4R,5R)-5-[(S)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-propionaldehyde (114825-78-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / CSA / Ambient temperature

2: 98 percent / KOH / Ambient temperature

3: (COCl)2, Et₃N / dimethylsulfoxide

With potassium hydroxide; oxalyl dichloride; camphor-10-sulfonic acid; triethylamine; In dimethyl sulfoxide;

DOI:10.1016/S0040-4039(00)96566-3

upstream raw materials:

(S)-2-[(4R,5R)-5-[(S)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-propan-1-ol

1,1-dimethoxy-1-(4-methoxyphenyl)ethane

Benzoic acid (S)-2-[(4R,5R)-5-[(S)-1-(4-methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-propyl ester

(2S,3R,4S,5R)-1,3,4-trihydroxy-5-(4-methoxybenzyloxy)-2,4-dimethylheptane

Downstream raw materials:

(E)-(S)-4-[(4R,5R)-5-[(S)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-2-methyl-pent-2-enoic acid ethyl ester

ethyl (2E,4S,5R,6R,7R)-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylidenedioxy>-2,4,6-trimethylnon-2-enoate

(2S,3R,4S,5R,6R,7R)-2,3-epoxy-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylenedioxy>-2,4,6-trimethylnonan-1-ol

((2S,3S)-3-{(S)-1-[(4R,5R)-5-[(R)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-2-methyl-oxiranyl)-methanol