(Z)-[3-(2,3-dichlorobenzylidene)-2-ethyl-7-methoxy-3H-inden-1-yl]acetic acid

Base Information

Chemical Name:(Z)-[3-(2,3-dichlorobenzylidene)-2-ethyl-7-methoxy-3H-inden-1-yl]acetic acid
CAS No.:177362-69-5
Molecular Formula:C₂₁H₁₈Cl₂O₃
Molecular Weight:389.278
Hs Code.:

Synonyms:(Z)-[3-(2,3-dichlorobenzylidene)-2-ethyl-7-methoxy-3H-inden-1-yl]acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-[3-(2,3-dichlorobenzylidene)-2-ethyl-7-methoxy-3H-inden-1-yl]acetic acid

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Technology Process of (Z)-[3-(2,3-dichlorobenzylidene)-2-ethyl-7-methoxy-3H-inden-1-yl]acetic acid

There total 9 articles about (Z)-[3-(2,3-dichlorobenzylidene)-2-ethyl-7-methoxy-3H-inden-1-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 177362-63-9
ethyl (2-ethyl-7-methoxy-3H-inden-1-yl)-acetate

: 177362-69-5
(Z)-[3-(2,3-dichlorobenzylidene)-2-ethyl-7-methoxy-3H-inden-1-yl]acetic acid

Guidance literature:: With sodium methylate; In methanol; for 2.66667h; Heating;
DOI:10.1021/jm960395q

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 177362-69-5
(Z)-[3-(2,3-dichlorobenzylidene)-2-ethyl-7-methoxy-3H-inden-1-yl]acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 24 percent / C₃H₇COONa / 150 °C

2: H₂ / 10percent Pd/C / methanol / 2280 Torr

3: Br₂, AcOH / 2.5 h / Ambient temperature

4: 30.0 g / polyphosphoric acid / 2.5 h / 100 °C

5: H₂, AcONa / Pd/C

6: 1.) NaH / 1.) toluene, 0 deg C, 1 h, 2.) toluene, reflux, 4 h

7: 85 percent / conc. H₂SO₄ / CHCl₃ / 0.67 h / Heating

8: 63 percent / NaOMe / methanol / 2.67 h / Heating

With PPA; C₃H₇COONa; sulfuric acid; hydrogen; bromine; sodium methylate; sodium acetate; sodium hydride; acetic acid; palladium on activated charcoal; In methanol; chloroform;
DOI:10.1021/jm960395q

Reference yield:

: 177363-08-5
2-ethyl-7-methoxy-1-indanone

: 177362-69-5
(Z)-[3-(2,3-dichlorobenzylidene)-2-ethyl-7-methoxy-3H-inden-1-yl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) toluene, 0 deg C, 1 h, 2.) toluene, reflux, 4 h

2: 85 percent / conc. H₂SO₄ / CHCl₃ / 0.67 h / Heating

3: 63 percent / NaOMe / methanol / 2.67 h / Heating

With sulfuric acid; sodium methylate; sodium hydride; In methanol; chloroform;
DOI:10.1021/jm960395q