N-(3-amino-4-methylphenyl)-4-(4-fluorophenyl)-2-(methylsulfonyl)-1H-imidazole-5-carboxamide

Base Information

Chemical Name:N-(3-amino-4-methylphenyl)-4-(4-fluorophenyl)-2-(methylsulfonyl)-1H-imidazole-5-carboxamide
CAS No.:1422175-94-7
Molecular Formula:C₁₈H₁₇FN₄O₃S
Molecular Weight:388.422
Hs Code.:

Synonyms:N-(3-amino-4-methylphenyl)-4-(4-fluorophenyl)-2-(methylsulfonyl)-1H-imidazole-5-carboxamide

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Chemical Property of N-(3-amino-4-methylphenyl)-4-(4-fluorophenyl)-2-(methylsulfonyl)-1H-imidazole-5-carboxamide

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Technology Process of N-(3-amino-4-methylphenyl)-4-(4-fluorophenyl)-2-(methylsulfonyl)-1H-imidazole-5-carboxamide

There total 1 articles about N-(3-amino-4-methylphenyl)-4-(4-fluorophenyl)-2-(methylsulfonyl)-1H-imidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 95-80-7,71111-07-4
4-methylbenzene-1,3-diamine

: 1422175-22-1
4-(4-fluorophenyl)-2-(methylsulfonyl)-1H-imidazole-5-carboxylic acid

: 1422175-94-7
N-(3-amino-4-methylphenyl)-4-(4-fluorophenyl)-2-(methylsulfonyl)-1H-imidazole-5-carboxamide

Guidance literature:: 4-(4-fluorophenyl)-2-(methylsulfonyl)-1H-imidazole-5-carboxylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.166667h; Cooling with ice;

With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;

4-methylbenzene-1,3-diamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield: 22.0%

: 1269667-57-3
4-chlorothieno[3,2-d]pyrimidine-7-carboxylic acid

: 1422175-94-7
N-(3-amino-4-methylphenyl)-4-(4-fluorophenyl)-2-(methylsulfonyl)-1H-imidazole-5-carboxamide

: 2592-95-2
benzotriazol-1-ol

: 1422175-95-8
4-((1H-benzo[d][1,2,3]triazol-1-yl)oxy)-N-(5-(4-(4-fluorophenyl)-2-(methylsulfonyl)-1H-imidazole-5-carboxamido)-2-methylphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: 4-chlorothieno[3,2-d]pyrimidine-7-carboxylic acid; N-(3-amino-4-methylphenyl)-4-(4-fluorophenyl)-2-(methylsulfonyl)-1H-imidazole-5-carboxamide; benzotriazol-1-ol; In N,N-dimethyl-formamide; acetonitrile; for 0.166667h; Cooling with ice;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; acetonitrile; for 48h; Cooling with ice;

Reference yield:

: 1422175-94-7
N-(3-amino-4-methylphenyl)-4-(4-fluorophenyl)-2-(methylsulfonyl)-1H-imidazole-5-carboxamide

: 1422175-93-6
C₂₅H₂₀FN₇O₄S₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; acetonitrile / 0.17 h / Cooling with ice

1.2: 48 h / Cooling with ice

2.1: ammonia / isopropyl alcohol / 6 h / 80 °C / Sealed tube

With ammonia; In N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;