C₂₀H₁₂BrCl₂N₃O₅S

Base Information

• Chemical Name: C₂₀H₁₂BrCl₂N₃O₅S
• CAS No.: 1452579-68-8
• Molecular Formula: C₂₀H₁₂BrCl₂N₃O₅S
• Molecular Weight: 557.208
• Mol file: 1452579-68-8.mol

Synonyms:C₂₀H₁₂BrCl₂N₃O₅S

Chemical Property of C₂₀H₁₂BrCl₂N₃O₅S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₁₂BrCl₂N₃O₅S

There total 3 articles about C₂₀H₁₂BrCl₂N₃O₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-((4-nitrophenoxy)methyl)-5-bromo-1H-benzimidazole (1160557-15-2) + 2,4-Dichlorobenzenesulfonyl chloride (16271-33-3) → C20H12BrCl2N3O5S (1452579-68-8) + C20H12BrCl2N3O5S (1452579-83-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at -5 - 0 ℃;

DOI:10.1016/j.bmcl.2013.06.072

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → C20H12BrCl2N3O5S (1452579-68-8) + C20H12BrCl2N3O5S (1452579-83-7)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 50 °C

2: sodium hydroxide / ethanol / 20 °C

3: tetrabutyl-ammonium chloride / toluene; water / 160 °C / Microwave irradiation

4: sodium hydride / tetrahydrofuran / -5 - 0 °C

With tetrabutyl-ammonium chloride; sodium hydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; water; acetone; toluene;

DOI:10.1016/j.bmcl.2013.06.072

Reference yield:

ethyl 4-nitrophenoxyacetate (19076-89-2) → C20H12BrCl2N3O5S (1452579-68-8) + C20H12BrCl2N3O5S (1452579-83-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 20 °C

2: tetrabutyl-ammonium chloride / toluene; water / 160 °C / Microwave irradiation

3: sodium hydride / tetrahydrofuran / -5 - 0 °C

With tetrabutyl-ammonium chloride; sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol; water; toluene;

DOI:10.1016/j.bmcl.2013.06.072

upstream raw materials:

4-nitro-phenol

ethyl 4-nitrophenoxyacetate

2-((4-nitrophenoxy)methyl)-5-bromo-1H-benzimidazole

2,4-Dichlorobenzenesulfonyl chloride

Refernces